Angiogenesis is an important aspect of a variety of physiological and pathological processes; and depends on the alteration of the balance between pro-angiogenic and anti-angiogenic factors. The role of angiogenesis in the progression and metastasis of neoplasm is a well established phenomenon. With regards to oral squamous cell carcinoma, it is a field of ongoing research and requires validati...

introduction: the human papilloma virus (hpv) can play a role in the development of head and neck squamous cell carcinoma (scc). our aim was to assess the prevalence of hpv dna in scc of the larynx. the impact of hpv infection on patient survival was also evaluated.  materials and methods: this case-control study was performed in 44 patients with scc of the larynx (case group), while the contro...

Background: The most frequently mutated tumor suppressor gene found in human cancer is p53. In a normal situation, p53 is activated upon the induction of DNA damage to either arrest the cell cycle or to induce apoptosis. However, when mutated, p53 is no longer able to properly accomplish these functions. The aim of this study was to investigate the expression of p53 gene in cases of skin cancer...

background : angiogenesis is essential for the growth, invasion and metastasis of solid tumors. research on related factors such as microvessel density can be helpful in predicting a tumor's behavior. cd105 has been introduced as a marker of angiogenesis which stains vessels that are in the proliferating stage. there are some controversies about the relation of microvessel density and clinicopa...

India holds the highest rank in terms of incidence oral cancer. Early detection is essential to reduce mortality rate results late cancer diagnosis. Recent studies emphasize micronutrients or trace elements as harbingers squamous cell carcinoma (OSCC). These play a dual role proliferation and act anti-cancer agents. Magnesium (Mg) forms an component micronutrient family body. It has many functi...

OBJECTIVE To evaluate the value of sentinel lymph node biopsy in diagnosis of cervical metastasis in patients with early oral squamous cell carcinoma. METHODS Cochrane library, evidence-based medicine (EBM), PubMed, China national knowledge internet (CNKI) were searched for 2001 - 2011 literatures on sentinel lymph node biopsy in patients with oral squamous cell carcinoma as early diagnosis o...

BACKGROUND Oral squamous cell carcinomas are often heavily infiltrated by immune cells. The organization of B-cells, follicular dendritic cells, T-cells and high-endothelial venules into structures termed tertiary lymphoid structures have been detected in various types of cancer, where their presence is found to predict favourable outcome. The purpose of the present study was to evaluate the in...