نتایج جستجو برای: kit

تعداد نتایج: 29127  

Journal: :Cancer research 2006
Elliot B Sambol Grazia Ambrosini Rula C Geha Peter T Kennealey Penelope Decarolis Rachael O'connor Yuhsin V Wu Monica Motwani Jin-Hong Chen Gary K Schwartz Samuel Singer

Gastrointestinal stromal tumors (GIST) are characterized by activating mutations in the c-KIT gene which confers ligand-independent activation of the KIT receptor. Imatinib mesylate has been shown to effectively block constitutively active KIT and delay tumor growth. However, resistance to imatinib mesylate is emerging as a major clinical problem and novel therapies are needed. We report that t...

2016
Mingjun Du Sebastian Schmull Wentian Zhang Chenxi Wang Feng Lian Yao Chen Song Xue

Although the bone marrow mononuclear cell (BMMNC) is known as an ideal cell type for cell-based therapy for MI treatment, the effective subpopulation still remains unknown. Our study aimed at identifying the optimal subset of BMMNCs suited for cardiac regeneration. In this study, we observed that MI led to (i) a significant increase of the c-kit(+)AT2R(+) BMMNC subpopulation in mice and (ii) a ...

2014
Ying-Yu Ma Sheng Yu Xu-Jun He Yuan Xu Fang Wu Ying-Jie Xia Kun Guo Hui-Ju Wang Zai-Yuan Ye Wei Zhang Hou-Quan Tao

The aim of this study was to discuss the role of c-KIT mutation in the pathogenesis of gastrointestinal stromal tumors (GISTs) and analyze its correlation with proliferation and apoptosis. c-KIT and PDGFRA genotypes were examined by deoxyribonucleic acid sequencing. Immunohistochemistry was performed to determine the expression levels of Kit, Ki-67 (proliferation marker), and apoptotic protease...

Journal: :Diabetes 2015
Zhi-Chao Feng Alex Popell Jinming Li Jenna Silverstein Amanda Oakie Siu-Pok Yee Rennian Wang

The receptor tyrosine kinase c-Kit plays an integral role in maintaining β-cell mass and function. Although c-Kit receptor signaling promotes angiogenesis in multiple cell types, its role in islet vasculature is unknown. This study examines the effects of c-Kit-mediated vascular endothelial growth factor isoform A (VEGF-A) and islet vascularization on β-cell function and survival using in vitro...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2005
Chi Tarn Erin Merkel Adrian A Canutescu Wei Shen Yuliya Skorobogatko Martin J Heslin Burton Eisenberg Ruth Birbe Arthur Patchefsky Roland Dunbrack J Pablo Arnoletti Margaret von Mehren Andrew K Godwin

PURPOSE Gastrointestinal stromal tumors (GIST) are characterized by expressing a gain-of-function mutation in KIT, and to a lesser extent, PDGFR. Imatinib mesylate, a tyrosine kinase inhibitor, has activity against GISTs that contain oncogenic mutations of KIT. In this study, KIT and PDGFRalpha mutation status was analyzed and protein modeling approaches were used to assess the potential effect...

Journal: :Molecular Vision 2008
Dai Miyazaki Takeshi Tominaga Keiko Yakura Chuan-Hui Kuo Naoki Komatsu Yoshitsugu Inoue Santa J. Ono

PURPOSE To determine the contribution of conjunctival mast cells to the allergen-specific inflammatory responses in eyes with allergic conjunctivitis and to test the hypothesis that mast cells act as mediators of the early phase response. METHODS The participation of mast cells in allergen-induced inflammatory cell recruitment was studied in an experimental murine model of allergic conjunctiv...

Journal: :Physiological reviews 2012
Johan Lennartsson Lars Rönnstrand

Stem cell factor (SCF) is a dimeric molecule that exerts its biological functions by binding to and activating the receptor tyrosine kinase c-Kit. Activation of c-Kit leads to its autophosphorylation and initiation of signal transduction. Signaling proteins are recruited to activated c-Kit by certain interaction domains (e.g., SH2 and PTB) that specifically bind to phosphorylated tyrosine resid...

2015
Zhi-Chao Feng Alex Popell Jinming Li Jenna Silverstein Amanda Oakie Rennian Wang

The receptor tyrosine kinase c-Kit plays an integral role in maintaining b-cell mass and function. Although c-Kit receptor signaling promotes angiogenesis in multiple cell types, its role in islet vasculature is unknown. This study examines the effects of c-Kit–mediated vascular endothelial growth factor isoform A (VEGF-A) and islet vascularization on b-cell function and survival using in vitro...

2015
Maria Isabel Carvalho Isabel Pires Marlene Dias Justina Prada Hugo Gregório Luis Lobo Felisbina Queiroga

In this study 80 malignant CMT were submitted to immunohistochemical detection of CD3, c-kit, VEGF, and CD31, together with clinicopathological parameters of tumor aggressiveness. CD3+ T-cells and c-kit overexpression revealed a positive correlation with VEGF (r = 0.503, P < 0.0001; r = 0.284, P = 0.023 for CD3 and c-kit, resp.) and CD31 (r = 0.654, P < 0.0001; r = 0.365, P = 0.003 for CD3 and ...

Journal: :Blood 2007
Thomas Jahn Simran Sindhu Stacie Gooch Petra Seipel Philip Lavori Erica Leifheit Kenneth Weinberg

In vivo analyses of thymopoiesis in mice defective in signaling through Kit and gammac or Kit and IL-7Ralpha demonstrate synergy and partial complementation of gammac or IL-7-mediated signaling by the Kit signaling pathway. Our molecular analysis in T-lymphoid cells as well as in nonhematopoietic cells shows that Kit and IL-7R signaling pathways directly interact. KL-mediated activation of Kit ...

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