Preparation and in vitro characterization of floating microparticles loaded with cimetidine (FMC) for oral delivery was the objective of this study. Non-solvent addition coacervation technique using hydroxypropylmethylcellulose (HPMC) as the rate controlling polymer was employed to achieve FMC. Three formulations of FMC were prepared and optimized regarding encapsulation efficiency and dissolut...

Memory is a ubiquitous phenomenon in biological systems in which the present system state is not entirely determined by the current conditions but also depends on the time evolutionary path of the system. Specifically, many memorial phenomena are characterized by chemical memory reactions that may fire under particular system conditions. These conditional chemical reactions contradict to the ex...

Multi-scale process modeling is very appealing methodology for process optimization since it highlights certain issues that remain unexplored with conventional methodologies and debottlenecks certain potentialities that remain unexploited in chemical plants. In this work, a kinetic model with 2400 reactions and 140 species is implemented in a proper reactor network to characterize the thermal f...

This paper provides a model of the crystallization kinetics polyamide 6 (PA6), including primary and secondary crystallization, lamellar thickness distribution, evolution mobile rigid fractions amorphous phase. The includes two-phase structure, monoclinic α-phase pseudo-hexagonal γ-meso phase, which depend on thermal history during solidification. is parameterized with experimental results from...

The aim of the study is to construct a mathematical model kinetics multiple ethanol intake based on kinetic equation zero-order elimination with absorption and irrevocable first-order deficiency, as well its implementation in format computer program. Analytical modeling oral administration performed basis this equation. In course modeling, summation method was developed that allows perform desc...