ion channels play a major role in the regulation of t cell function in health and disease. in a computer-based model, established to simulate t cells’ membrane potential (vm) generation, we discovered a discrepancy between the simulation and patch-clamp recordings. the predicted vm was more hyperpolarized than the measured vm, indicating that a yet unknown, depolarizing ion current might contri...

celiac disease has been associated with other autoimmune disorders such as autoimmune hepatitis, moreover it is known that t cell mediated immune response to dietary gluten and released cytokines are important for the entheropathy seen in celiac disease. we investigated celiac autoantibodies in patients with autoimmune hepatitis (aih), and chronic hepatitis b (chb). sera from 84 patients with a...

myelofibrosis is reported in patents with primary hyperparathyroidism. it is also was reported in patents with sec- ondary hyperparathyroidism due to end-stage renal disease or vitamin d dependent rickets .we present a case of celiac disease and osteomalacia which leads to secondary hyperparathyroidism and myelofibrosis.

purpose : to present the conjunctival aphthous ulceration in behçet’s disease (bd) case report : a 36-year-old woman with a known history of bd presenting an isolated, monosymptomatic conjunctival bulbar aphthosis. the eye was photophobic and painful. the lesion appeared four days prior to the consultation and measured 3.5 to 1.5 mm, which was totally excised and underwent pathological investig...

recent developments in medicine have given us a better insight into a group of disorders known as autoimmune diseases. in particular, advances have occurred in our understanding of the autoimmune inner ear disease (aied). in this article, the authors review the different postulated theories in the pathogenesis of this disease. the clinical presentation, the available para-clinical diagnostic to...

conclusion prompt diagnosis and treatment of skeletal tb are important to prevent serious bone and joint destruction and severe neurologic sequels. patients and methods in this study, epidemiologic aspects, clinical manifestations, laboratory tests and radiologic studies of cases with documented tuberculosis spondylitis in loghman hospital were evaluated. results of our patients, 25 (62.5%) wer...

background gaucher’s disease (g.d.) is an autosomal recessive disorder resulting from the accumulation of glucocerebrosidase in the cells of macrophage-monocyte system as a result of a deficiency in lysosomal glucocerebrosidase. this enzyme is encoded by a gene on chromosome-1. here we report a case of gaucher’s disease .g.d is rare in yazd. case reports we reported a patient that presented wit...

â  â celiac disease (cd) was traditionally believed to be a chronic enteropathy, almost exclusively affecting people of european origin. celiac disease is the permanent intolerance to dietary gluten, the major protein component of wheat. the availability of new, simple, very sensitive and specific serological tests has shown that cd is as common in middle eastern countries as in europe, austral...