Acute kidney injury (previously known as acute renal failure) is a common complication in hospitalized patients, and its incidence has risen significantly in the past 15 yr. Despite significant technical advances in therapeutics, the mortality and morbidity rates associated with acute kidney injury remain dismally high and have not appreciably improved during the past four decades. Although the...

It has been postulated that developmental pathways are reutilized during repair and regeneration after injury, but functional analysis of many genes required for kidney formation has not been performed in the adult organ. Mutations in SALL1 cause Townes-Brocks syndrome (TBS) and nonsyndromic congenital anomalies of the kidney and urinary tract, both of which lead to childhood kidney failure. Sa...

objective(s):there are a few previously reported studies about the effect of nigella sativa oil on renal ischemia-reperfusion injury (iri). the aim of the present study was to test the hypothesis whether pre- or post-treatment with n. sativa hydroalcoholic extract (nse) would reduce tissue injury and oxidative damages in a clinically relevant rat model of renal iri.    materials and methods: ir...

background: cystatin c (cys c) has been implicated as a prognostic marker in cardiovascular disease. the aim of this study was to evaluate the value of cys c as a marker of acute kidney injury (aki) in acute heart failure (ahf), the impact of cys c and n-terminal probrain natriuretic peptides (nt-probnp) on in-hospital and 12 months mortality were also investigated. materials and methods: a tot...

conclusions where there is a relationship between two longitudinal and survival responses, joint modeling can estimate it. background admission to the icu (intensive care unit) is frequently complicated by early aki (acute kidney injury). the development of aki following cardiac surgery is particularly associated with increased mortality and morbidity. according to akin (acute kidney injury net...

INTRODUCTION Kidney injury affects renal excretion of plasma analytes and metabolic waste products with grave pathologic consequences. Early detection, thus of kidney injury is essential for injury specific intervention that may avert permanent renal damage and delay progression of kidney injury. We aimed to evaluate Kidney Injury Molecule-1 (KIM-1) and Microalbuminuria (MAU), as biomarkers of ...

In most patients, wasp stings cause local reactions and rarely anaphylaxis. Acute kidney injury and rhabdomyolysis are unusual complications of wasp stings. We report a case of acute kidney injury and rhabdomyolysis secondary to multiple wasp stings. A 55-year-old farmer developed multi organ dysfunction with acute kidney injury and rhabdomyolysis 3 days after he had sustained multiple wasp sti...

BACKGROUND Acute kidney injury is a frequent postoperative complication that confers increased mortality, morbidity, and costs. The purpose of this study was to evaluate whether preoperative statin use is associated with a decreased risk of postoperative acute kidney injury. METHODS We assembled a retrospective cohort of 98,939 patients who underwent a major open abdominal, cardiac, thoracic,...

A paucity of literature exists on risk factors for mortality in charcoal burning suicide. In this observational study, we analyzed the data of 126 patients with charcoal burning suicide that seen between 2002 and 2013. Patients were grouped according to status of renal damage as acute kidney injury (N = 49) or non-acute kidney injury (N = 77). It was found that patients with acute kidney injury...

OBJECTIVE To evaluate the prevalence and outcome of acute kidney injury in paediatric intensive care units using the modified RIFLE score (pRIFLE). DESIGN Historical cohort study. SETTING A paediatric intensive care unit in a regional Hong Kong hospital. PATIENTS; All paediatric patients aged 1 month to 18 years admitted to a local paediatric intensive care unit in the years 2005 to 2007. M...