Mice treated with buthionine sulfoximine, an inhibitor of glutathione synthesis, showed striking alterations of morphology of lung type 2 cell lamellar bodies (swelling and disintegration) and mitochondria (degeneration) and of lung capillary endothelial cells (mitochondrial swelling). These effects probably may be ascribed to glutathione deficiency; administration of glutathione monoester prot...

The present experiment was carried out to investigate the effectivness of -lipoic acid in allevating the toxicity of aluminium phosphide on biochemical parameters, free radicals and enzyme activities in plasma, liver and kidney of male rats. Animals were orally treated with aluminium phosphide, -lipoic acid and their combination for 30 consecutive days. Treatment with aluminium phosphide led to...

Rats fed a galactose-rich diet have been used for several years as a model for diabetes to study, particularly in the eye, the effects of excess blood hexoses. This study sought to determine the utility of galactosemia as a model for oxidative stress in extraocular tissues by examining biomarkers of oxidative stress in galactose-fed rats and experimentally-induced diabetic rats. Sprague-Dawley ...

3-Methycholanthrene, a potent polycyclic aromatic carcinogen, induces the activities of Phase I and Phase II drug metabolism enzymes in the body. Increase in the activities of Cytochrome P-450, a most important Phase I enzyme, by 3-Methylcholanthrene in liver and kidney tissues are well established. However the effect of this aromatic carcinogen on noncytochrome mediated drug metabolizing enzym...

: Multi-walled carbon nanotubes (MWCNTs) are being utilized in various fields. With regard to their numerous applications, MWCNT-induced toxicity has not been extensively investigated. Thus, the present study sheds light on protective effect of caffeic acid (CA) mitochondrial kidney caused by MWCNTs Wistar rats employing MTT assay as well reactive oxygen species (ROS) indices, based measuring g...

Objective(s): Populus species have various pharmacological properties, including antioxidant activity. In this study, the effects of Populus tomentiglandulosa extract (PTE) on histopathology and antioxidant enzymes in the rat liver and kidney were examined.  Materials and Methods: Sprague-Dawley rats were assigned to three groups; (1) no...

Background and Aims: Nephrotoxicity is an adverse effect, which may occur with the use of tenofovir/lamivudine/efavirenz (TLE) in treatment human immune deficiency virus (HIV) infection. Curcumin (CUM), isolate Curcuma longa L. used folk medicine for ailments. This study attempts to establish whether CUM supplementation can protect against a rat model TLE-induced nephrotoxicity. Materials Metho...

Glutathione deficiency, induced in adult mice by administering buthionine sulfoximine (an inhibitor of glutathione synthesis), led to a rapid and substantial increase in ascorbate in the liver. This effect was apparent 2-4 hr after giving the inhibitor; subsequently, the level of ascorbate decreased and that of dehydroascorbate increased markedly, supporting the conclusion that glutathione func...

The trivalent arsenic glutathione complexes arsenic triglutathione, methylarsonous diglutathione, and dimethylarsinous glutathione are key intermediates in the mammalian metabolism of arsenite and possibly represent the arsenic species that are transported from the liver to the kidney for urinary excretion. Despite this, the comparative stability of the arsenic-sulfur bonds in these complexes h...

Anacardium occidentale (Cashew) is a plant reported to show several biological activities. The aim of this study examine the effects methanol extract nut shell on antioxidant status and histological features in cardiac renal tissues rats. Shells were obtained from nut, air-dried, pulverized, subjected Soxhlet extraction obtain (AONSE). Forty-five male Wistar rats divided into nine groups (5 eac...