Over the last few years, the ETS transcription factor ERG has emerged as a major regulator of endothelial function. Multiple studies have shown that ERG plays a crucial role in promoting angiogenesis and vascular stability during development and after birth. In the mature vasculature ERG also functions to maintain endothelial homeostasis, by transactivating genes involved in key endothelial fun...

Translocations fusing the strong androgen-responsive gene, TMPRSS2, with ERG or other oncogenic ETS factors may facilitate prostate cancer development. Here, we studied 18 advanced prostate cancers for ETS factor alterations, using reverse transcription-PCR and DNA and RNA array technologies, and identified putative ERG downstream gene targets from the microarray data of 410 prostate samples. O...

Blood vessel stability is essential for embryonic development; in the adult, many diseases are associated with loss of vascular integrity. The ETS transcription factor ERG drives expression of VE-cadherin and controls junctional integrity. We show that constitutive endothelial deletion of ERG (Erg(cEC-KO)) in mice causes embryonic lethality with vascular defects. Inducible endothelial deletion ...

Purpose: Fusion of the TMPRSS2 gene with the ERG oncogene and aberrant DNAmethylation patterns are commonly found in prostate cancer. The aim of this study was to analyze the relationship between ERG expression, DNA methylation of three biomarkers, and clinicopathologic features of prostate cancer. Experimental Design: Immunohistochemistry for ERG protein was conducted as a surrogate for TMPRSS...

What Is the mfERG? The electroretinogram (ERG) is a mass potential, the result of the summed electrical activity of the cells of the retina. Typically, the clinical ERG is elicited by full-field (Ganzfeld) flashes of light. With an appropriate selection of test and background lights, rod and cone function can be assessed separately. As the ganglion cells contribute relatively little to the full...

PURPOSE To determine the reliability of the Dawson, Trick, and Litzkow (DTL) electrode in electroretinographic recordings (ERG) in subjects of all ages, we evaluated ERG responses obtained with the contact lens (CL) and DTL electrodes and estimated a DTL/CL ratio for each sample. METHODS Seventy-nine volunteers aged 2-84 years (79 normal eyes) were recruited for the study. Electroretinographi...

Oncogenic activation of the ETS Related Gene (ERG) in humans was originally identified insubsets of Ewing sarcomas, myeloid leukemias and, recently, in the majority of prostatecancers. Expression of human ERG protein and consequently its functions in normal anddisease states needs to be better understood in light of its suggested role in cell differentiationand proliferation. He...

PURPOSE Fusion of the TMPRSS2 gene with the ERG oncogene and aberrant DNA methylation patterns are commonly found in prostate cancer. The aim of this study was to analyze the relationship between ERG expression, DNA methylation of three biomarkers, and clinicopathologic features of prostate cancer. EXPERIMENTAL DESIGN Immunohistochemistry for ERG protein was conducted as a surrogate for TMPRS...

AIM Prostate cancer (PCa) is the second most common cancers in men worldwide. Its incidence can be influenced by several risk factors including genetic susceptibility. Therefore the search for the expression of a certain gene (ERG) and its rearrangement could give us clues for proper identification of PCa. And the study of ERG expression and its comparison to FISH in Egyptian patients can show ...