Candida albicans and the emerging non-albicans Candida spp. have significant clinical relevance among many patient populations. Current treatment guidelines include fluconazole as a primary therapeutic option for the treatment of these infections, but it is only fungistatic against Candida spp. and both inherent and acquired resistance to fluconazole have been reported. Such mechanisms of resis...

BACKGROUND Pediatric Candida infections are associated with worse clinical outcomes and increased costs. Yet, it is not definitively known if particular species are associated with more severe illness. Differential risk factor exposures among the species group may also exist. We aimed to determine whether certain Candida species are more strongly associated with worse outcomes, and whether cert...

OBJECTIVES It is thought that widespread use of 'over-the-counter' azoles may increase the incidence of resistant Candida species such as Candida glabrata. Infections with species other than Candida albicans frequently do not respond to standard azole treatments. Intravaginal nystatin is an option but is no longer available in the UK. In this paper, the authors review the prevalence of non-albi...

BACKGROUND Vulvovaginal Candidiasis (VVC) is a frequent, complex and cumbersome condition that can cause physical and psychological distress for the involved individual. Candida albicans was reported as the most common agent of VVC yet it seems that we are recently encountering changes in the pattern of Candida species in VVC. OBJECTIVES In this study we assessed different species of Candida ...

OBJECTIVE To determine the frequency of Candida albicansin patients with funguria. STUDY DESIGN Descriptive cross-sectional study. PLACE AND DURATION OF STUDY Department of Microbiology, Sindh Institute of Urology and Transplantation, from July to December 2012. METHODOLOGY Patients’ urine samples with fungus/Candida were included. Candida albicans was identified by the production of tubu...

background: antimicrobial effi cacy of photodynamic therapy (pdt) depends on both the photosensitizer (ps) and laser parameters. in the present study, antimicrobial effectiveness of pdt with different concentrations of two pss was compared. materials and methods: in this study, we employed fi fty-nine 6-week-old male wistar rats. all except the negative and overall control groups were immunosup...

Objective: Invasive fungal infections caused by Candida species have increased significantly. Candidemia is not only associated with a mortality, but also extends the duration of hospital stay and increases the cost for medical care. Although, the clinical presentations of the patients with candidemia caused by Candida albicans and non-albicans Candida species are indistinguishable, the suscept...

background: candida albicans (c. albicans) may have cariogenic potential but its role in caries etiology has not been established. the aim of this study was to determine c. albicans in supragingival dental plaque and infected dentine of cervical and proximal in early childhood caries (ecc). methods: this cross-sectional study was carried out on 6o children aged 2-5 years, which were divided int...