Fatty acid synthase (FASN, UniProt ID: P49327) is a multienzyme dimer complex that plays a critical role in lipogenesis. Consequently, this lipogenic enzyme has gained tremendous biomedical importance. The role of FASN and its inhibition is being extensively researched in several clinical conditions, such as cancers, obesity, and diabetes. X-ray crystallographic structures of some of its domain...

The Streptomyces glaucescens beta-ketoacyl-acyl carrier protein (ACP) synthase III (KASIII) initiates straight- and branched-chain fatty acid biosynthesis by catalyzing the decarboxylative condensation of malonyl-ACP with different acyl-coenzyme A (CoA) primers. This KASIII has one cysteine residue, which is critical for forming an acyl-enzyme intermediate in the first step of the process. Thre...

Some plants produce methylketones as potent defense compounds against various insects. Wild tomato (Solanum habrochaites), a relative of the cultivated tomato (Solanum lycopersicum), synthesizes large amounts of 2-methylketones in its glandular trichomes, but cultivated tomato trichomes contain little or no methylketones. Two enzymes, Solanum habrochaites methylketone synthase1 (ShMKS1) and ShM...

Mycobacterium tuberculosis β-ketoacyl-ACP synthase I (KasA) involves in mycolic acid biosynthesis for cell wall maintenance; hence, it is a critical target TB drug design. Thiolactomycin (TLM) and derivatives are the known standard KasA enzyme activity inhibitors. However, TLM analogues have poor against protein. Indazole sulphonamide chemotype (JSF-3285/JFX) was recently reported as promising ...

The β-ketoacyl CoA synthase encoded by the KCS genes is a rate-limiting enzyme for synthesis of very-long-chain fatty acid (VLCFA), which catalyzes VLCFA elongation. Yellow horn (Xanthoceras sorbifolium) horticultural tree species known its kernel oil, has strong resistance to drought, cold, high temperature, and saline-alkali. conserved domain FAE1-CUT1-RPPA ACP-syn-III_C gene family were used...