Crude cell-free preparations of Pseudomonas saccharophila grown on n-arabinose oxidize n-arabinose to ol-ketoglutaric acid (1). n-Arabonic acid has been identified as an intermediate in this reaction. The investigations described in this communication are concerned with the mechanism of the conversion of Larabonate to a-ketoglutarate. Evidence is presented for the intermediate formation of &2-k...

The NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation of the 15(S)-hydroxyl group of prostaglandin E2 (PGE2), converting the pro-inflammatory PGE2 to the anti-inflammatory 15-keto-PGE2 (an endogenous ligand for peroxisome proliferator-activated receptor-gamma [PPAR-γ]). To evaluate the significance of 15-PGDH/15-keto-PGE2 cascade in liver inflammation and ti...

Introduction Conclusions References

The title compound, C(12)H(12)Cl(2)N(2)O(3), crystallizes as a non-merohedral twin with a twinning ratio of 0.51:0.49. The mol-ecule adopts a keto-hydrazo tautomeric form stabilized by an intra-molecular N-H⋯O hydrogen bond. The configuration around the N-N bond is trans.

Euglycemic Diabetic Keto Acidosis is a rare form of DKA seen in patients who are taking SGLT-2 inhibitor medication for the treatment diabetes mellitus. It life-threatening condition and should be diagnosed early.

Protein dynamics are likely to play important, regulatory roles in many aspects of photosynthetic electron transfer, but a detailed description of these coupled protein conformational changes has been unavailable. In oxygenic photosynthesis, photosystem I catalyzes the light-driven oxidation of plastocyanin or cytochrome c and the reduction of ferredoxin. A chlorophyll (chl) a/a' heterodimer, P...

The plasma concentration of 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), the stable hydration product of prostacyclin, was measured by radioimmunoassay in 111 healthy children aged between 1 day and 16 years and in 21 healthy adults aged between 21 and 72 years. The 6-keto-PGF1 alpha levels in children up to age 16 years were higher than those in adults. During the first 4 days of life th...

Aspirin treatment of cultured endothelial cells from the umbilical vein increased the adherence of 51Cr-platelets when thrombin was present. If the cyclooxygenase activity of endothelium was inhibited by aspirin, as it is in the platelet, reduction of endogenous prostacyclin (PGI2) production could have been responsible. By correlating thrombin-induced adherence of platelets to endothelial mono...

The study of tautomerics equilibria is vital importance as tautomeric compounds reactivity highly depends on the proportion each tautomer. Herein, equilibrium 3-phenyl-2,4-pentanedione was studied theoretically by b3lyp/6-31+g(d)methods. effect four solvents considered (water, methanol, carbon tetrachloride and Cyclohexane).The takes place through four-membered ring transition state. barrier he...

A comprehensive picture of the ultrafast nonradiative decay mechanisms of three cytosine tautomers (amino-keto, imino-keto, and amino-enol forms) is revealed by high-level ab initio potential energy calculations using the multistate (MS) CASPT2 method and also by on-the-fly excited-state molecular dynamics simulations employing the CASSCF method. To obtain a reliable potential energy profile al...