The term corneal dystrophy embraces a heterogenous group of bilateral genetically determined non-inflammatory corneal diseases that are restricted to the cornea. The designation is imprecise but remains in vogue because of its clinical value. Clinically, the corneal dystrophies can be divided into three groups based on the sole or predominant anatomical location of the abnormalities. Some affec...

Photodynamic therapy (PDT) is a noninvasive treatment that utilizes light treatment along with application of a photosensitizing agent. In dermatology, PDT is commonly used and approved for the treatment of oncological conditions such as actinic keratosis, Bowen disease and superficial basal cell carcinoma. In the last 2 decades however, PDT has also been used for the treatment of several nonne...

Keratosis lichenoides chronica (KLC) is a rare keratotic disorder of unknown origin. Effective treatment has not been established yet. Here, we present adult-onset KLC, which was treated by narrow-band ultraviolet B (NB-UVB) monotherapy. Although NB-UVB was reported to be effective for pediatric-onset KLC, it has not been clear if this regimen is also useful for adult-onset type because pediatr...

A survey, using the rabbit ear, of the comedogenicity and irritancy of several groups of skin care products indicates that many contain follicular and surface pithelial irritating ingredients. These ingredients fall into several chemical classes. Certain generalizations can be deduced by examining the results: (1) medium-chain-length fatty acids are more potent than shortor long-chain fatty aci...

Background. Darier's disease (DD), also known as Keratosis Follicularis or Darier-White disease, is a rare disorder of keratinization. DD can present as a generalized autosomal dominant condition as well as a localized or segmental postzygotic condition (Vázquez et al., 2002). Clinical features of DD include greasy, warty papules and plaques on seborrheic areas, dystrophic nails, palmo-plantar ...

BACKGROUND Acne vulgaris has an important genetic predisposition, as well as keratosis pilaris. Clinical observations suggest that patients with keratosis pilaris have less frequent or less severe acne breakouts; however, we found no studies on this regard OBJECTIVE To determine if the presence of keratosis pilaris is associated with lower prevalence and severity of acne. METHODS A cross-se...

Distributed diagnostic protocols face the challenges posed by current rise in transient fault rates. The issue of discriminating between transient and intermittent faults becomes essential to avoid unnecessary isolations which reduce system resiliency and thus reliability. This issue can be solved using proper count and threshold mechanisms [1], that expect underlying diagnostic protocols to ev...

We model systemic risk by including a common factor exposure to market-wide shocks and an exposure to tail dependence effects arising from linkages among extreme stock returns. Specifically our model allows for the firm-specific impact of infrequent and extreme events. When a jump occurs, its impact is in the same direction for all firms (either positive or negative), but its size and volatilit...