BACKGROUND Lobular keloid appears to be a consequence of hypertrophic inflammation secondary to ear piercings performed under unsterile conditions. We wish to understand the pathogenesis of lobular keloids and report operative outcomes with a literature review. METHODS A retrospective review identified 40 cases of lobular keloids between January, 2005 and December, 2010. Patient records were ...

Numerous treatment modalities have been used to treat keloids and hypertrophic scars, but optimal treatment has not yet been established. The failure of achieving better therapeutic results in treating keloids highlights the essential problem that the pathogenetic mechanisms causing keloids remain unclear. Increased understanding at the molecular level will lead to the development of new therap...

Keloids have been classically considered an aberrant wound-healing response, particularly common in Black or Asian populations. There are currently no targeted treatments for keloids due to their elusive pathogenesis. To further support immune-basis hypothesis keloids, we performed global phenotyping of keloid patients (n=27) and controls (n=23), primarily African Americans, using RNA-Seq Olink...

Keloids are most commonly located in the ears (44.4%), followed by the thorax (33.3%), and shoulders (7.4%) [1]. Keloids, along with hypertrophic scars, are caused by an aberration in the normal wound healing process and inflict great discomfort on the patient [2]. Abnormal scars may cause pain or pruritus, disturb the range of motion, diminish sensation, or cause aesthetic deformities that may...

Keloid disorder (KD) is an inherited wound healing ailment, frequently seen among Africans /African Americans and Asians. Genetics of this disorder continues to be obscure and poorly understood. Clinical manifestation of KD is quite variable and very diverse, spanning from individuals with one or very few small keloidal lesions, to those with numerous and very large lesions covering large porti...

Objective. The aim of the study is to investigate the possible associations between the blood groups ABO and Rhesus systems and the presence of keloids in patients with black skin. Method. This case-control study was conducted between September 2007 and August 2011 comparing dermatologic outpatients with keloids to matched controls recruited in preanesthetic consultation at Tokoin Teaching Hosp...

PURPOSE OF REVIEW Abnormal scarring remains a poorly understood but functional and aesthetic consequence of surgical and traumatic wounds. The purpose of this review is to describe the current state of the science behind the prevention and management of these scars. RECENT FINDINGS A recent update in the International Clinical Recommendations on Scar Management provides a wealth of informatio...

OBJECTIVE The objective of this retrospective study was to evaluate the efficacy of the authors' combination therapy protocol for keloid treatment. DESIGN Retrospective. SETTING Plastic surgery office-based outpatient setting in New York City. PATIENTS Forty patients with 44 keloid scars requiring surgical excision. INTERVENTIONS Keloid scars were treated using surgical excision, platel...

BACKGROUND The calcium channel blocker, verapamil stimulates procollagenase synthesis in keloids and hypertrophic scars. AIM To study the effect of verapamil in the treatment of hypertrophic scars and keloids and to evaluate the effect of verapamil on the rate of reduction of hypertrophic scars and keloids in comparison with triamcinolone. METHODS The study was a randomized, single blind, p...

Prophylaxis and therapy of keloids present a big challenge for medicine, despite the increasing knowledge about their pathogenesis. There are a lot of therapeutic methods but their effectiveness is still limited and unsatisfactory. These methods are divided into surgical, pharmacological and physical ones as well as the most frequently applied combined therapy, which is the most effective one. ...