Spectral Karyotyping (SKY) (1–7) and Comparative Genomic Hybidization (CGH) (8– 11) are complementary fluorescent molecular cytogenetic techniques that have revolutionized the detection of chromosomal abnormalities. SKY permits the simultaneous visualization of all human or mouse chromosomes in a different color, facilitating the detection of chromosomal translocations and rearrangements (Figur...

The establishment of human diploid chromosome number (Tjio and Levan, 1956), have led to the foundations of human cytogenetics. Since then, due to the rapid developments of new techniques for chromosome analysis, many other chromosome disorders were recognized. The introduction of banding techniques, yielding a highly reproducible banding pattern, allowed the reliable identification of every si...

An ultrasonic backscattered signal from material comprised of quasiperiodic scatterers exhibit redundancy over both its phase and magnitude spectra. This paper addresses the problem of estimating mean-scatterer spacing from the backscattered ultrasound signal using spectral redundancy characterized by the spectral autocorrelation (SAC) function. Mean-scatterer spacing estimates are compared for...

In this paper, we investigate the use of jitter estimation over short time intervals (short-term jitter) for voice pathology detection in the case of running or continuous speech. Short-term jitter estimations are provided by the spectral jitter estimator (SJE), which is based on a mathematical description of the jitter phenomenon. The SJE has been shown to be robust against errors in pitch per...

Ultrashort optical pulses are integral to various fields. Thus, the characterization of these pulses is crucial in understanding the results of experiments and applications using them. A diagnostic for laser systems was created to determine the shapes of ultrashort optical pulses using the principle of spectral shearing interferometry (SSI). By strongly chirping an optical pulse using a pair of...

The accuracy of quantitative stereological analysis tools such as the (physical) disector method substantially depends on the precise determination of the thickness of the analyzed histological sections. One conventional method for measurement of histological section thickness is to re-embed the section of interest vertically to its original section plane. The section thickness is then measured...

Space weathering causes the change in optical properties, such as darkening, reddening, and decrease of absorption depths of the planetary surfaces. Two competing processes have been proposed so far as the main mechanism of such space weathering; hydrogen irradiation by solar wind and bombardment of micrometeorites. We use the new data set obtained by Spectral Profiler (SP) onboard SELENE/Kaguy...