This study was aimed at investigating the effect of ethanol on oral bioavailability of kaempferol in rats, namely, at disclosing their possible interaction. Kaempferol (100 or 250 mg kg-1 bm) was administered to the rats by oral gavage with or without ethanol (600 mg kg-1 bm) co-administration. Intravenous administration (10 and 25 mg kg-1 bm) of kaempferol was used to determine the bioavailabi...

Diabetic retinopathy (DR) is one of the common and specific microvascular complications of diabetes. This study aimed to investigate the anti-angiogenic effect of kaempferol and explore its underlying molecular mechanisms. The mRNA expression level of vascular endothelial growth factor (VEGF) and placenta growth factor (PGF) and the concentrations of secreted VEGF and PGF were measured by qTR-P...

Bleaching of kaempferol by illuminated chloroplasts was observed at 380 nanometers. The photobleaching was stimulated by methyl viologen and suppressed by superoxide dismutase indicating the participation of O(2) (-) in the reaction. An electron transfer inhibitor on the oxidizing side of photosystem II, carbonylcyanide m-chlorophenylhydrazone (CCCP), stimulated the photobleaching and 3-(3,4-di...

Retinoblastoma is a pediatric retinal tumor caused by mutational inactivation of the tumor suppressor pRb, and the present study aims to examine the role of kaempferol in retinoblastoma and explore its underlying molecular mechanisms. The mRNA and protein expression levels were measured by quantitative real time PCR (qRT-PCR) and western blot, respectively; cell growth and invasion was determin...

A investigação fitoquímica do extrato metanólico das folhas de Annona dioica (Annonaceae) resultou na identificação dos flavonóides kaempferol (1), 3-O-[3",6"-di-O-p-hidroxicinamoil]β-galactopiranosil-kaempferol (2), 6"-O-p-hidroxicinamoil-β-galactopiranosil-kaempferol (3) e 3-O-β-galactopiranosil-kaempferol (4). As estruturas foram caracterizadas inequivocamente através de análises espectroscó...

Heat-treated leaves of Cassia alata were studied for any change in chemical constituents using sun dried leaves as the reference standard. A high concentration of a constituent was observed in the heat-treated leaves. Spectroscopic studies revealed the structure of the constituent as kaempferol 3-gentiobioside, which has not yet been detected in the Cassia species. In a stability study disappea...

Incubation systems were established to investigate the effects of quercetin, kaempferol, isoquercitrin and astragalin in Lysimachia clethroides Duby on the activities of CYP2E1 and CYP3A4 in rat liver microsomes in vitro. Probe substrates of 4-nitrophenol and testosterone as well as flavonoids at different concentrations were added to the incubation systems. After incubation, a validated high p...

tribulus terrestris l. var. orientalis (kerner) g. beck is widely used in the traditional medicine of many countries. several flavonoides are identified from the plant material. aerial parts which collected from northeast of iran are used in this study. three flavonoid glycosides were isolated and characterized. the flovonoids were found to be based on quercetin and kaempferol. flavonoid glycos...

the bioactivity of chemical extracts from silverleaf nightshade solanum elaeagnifolium cav. seeds and leaves were tested for herbicidal activities, through water and ethanol extracts, against portulaca oleracea l., corchorus olitorius l., convolvulus arvensis l.and echinochloa crus-galli (l.) found in most zea mays l.fields. characterization of the isolated constituents from ethanol extract was...

The rhizomes of Zingiber spectabile yielded a new dimeric flavonol glycoside for which the name kaempferol-3-O-(4″-O-acetyl)-α-L-rhamnopyranoside-(I-6,II-8)-kaempferol-3-O-(4″-O-acetyl)-α-L-rhamnopyranoside; spectaflavoside A (1) was proposed, along with kaempferol and its four acetylrhamnosides (2-6), demethoxycurcumin (7) and curcumin (8). The structure of spectaflavoside A was elucidated by ...