introduction: kainic acid (ka) induces neuropathological changes in specific regions of the mouse hippocampus comparable to changes seen in patients with chronic temporal lobe epilepsy (tle). according to different studies, the expression of a number of genes are altered in the adult rat hippocampus after status epilepticus (se) induced by ka. this study aimed to quantitatively evaluate changes...

let a; b; k 2 k and u ; v 2 u(k). we show for any idempotent e 2 k, ( a 0 b 0 ) is e-clean i ( a 0 u(vb + ka) 0 ) is e-clean and if ( a 0 b 0 ) is 0-clean, ( ua 0 u(vb + ka) 0 ) is too.

Kojic acid (KA) has been widely used as a quasi-drug ingredient. Possible promotion activity of KA was suggested on livers of mouse and rat by findings obtained in genotoxicity and carcinogenicity studies performed thus far. Therefore, in order to examine safety as a quasi-drug ingredient, we investigated the presence of initiation activity in rat liver and the photo-genotoxicity and carcinogen...

Let A be a connected graded algebra and let E denote its Extalgebra L i Ext i A(kA, kA). There is a natural A∞-structure on E, and we prove that this structure is mainly determined by the relations of A. In particular, the coefficients of the A∞-products mn restricted to the tensor powers of ExtA(kA, kA) give the coefficients of the relations of A. We also relate the mn’s to Massey products.

Degradation of the extracellular matrix (ECM) protein laminin contributes to excitotoxic cell death in the hippocampus, but the mechanism of this effect is unknown. To study this process, we disrupted laminin gamma1 (lamgamma1) expression in the hippocampus. Lamgamma1 knockout (KO) and control mice had similar basal expression of kainate (KA) receptors, but the lamgamma1 KO mice were resistant ...

Kainic acid-induced status epilepticus (KA-SE) in mature rats results in the development of spontaneous recurrent seizures and a pattern of cell death resembling hippocampal sclerosis in patients with temporal lobe epilepsy. In contrast, KA-SE in young animals before postnatal day (P) 18 is less likely to cause cell death or epilepsy. To investigate whether changes in neuronal excitability occu...

Let R(Ka,b, Kc,d) be the minimum number n so that any n-vertex simple undirected graph G contains a Ka,b or its complement G′ contains a Kc,d. We demonstrate constructions showing that R(K2,b, K2,d) > b + d + 1 for d ≥ b ≥ 2. We establish lower bounds for R(Ka,b, Ka,b) and R(Ka,b, Kc,d) using probabilistic methods. We define R′(a, b, c) to be the minimum number n such that any n-vertex 3-unifor...

Apigenin (5,7,4'-trihydroxyflavone) is a principal ingredient of Cirsium japonicum. These experiments were performed to determine whether apigenin has neuroprotective effects against kainic acid (KA)-induced excitotoxicity in vitro and in vivo. Intraperitoneal (i.p.) administration of apigenin (25, 50 mg/kg) decreased the seizure scores induced by KA injection (40 mg/kg, i.p.) in mice. In addit...

Glutamate excitotoxicity plays a key role in the induction of neuronal cell death occurring in many neuropathologies, including epilepsy. Systemic administration of the glutamatergic agonist kainic acid (KA) is a well characterized model to study epilepsy-induced brain damage. KA-evoked seizures in mice result in hippocampal cell death, with the exception of some strains that are resistant to K...

Introduction Previous studies have shown that seizure can induce cognitive impairment. On the other hand, soy phytoestrogens, which are mainly found in soybean (Glycine max (L.) Merr.), have beneficial effects on the nervous system. However, little is known about their probable effects on seizure. The present study aimed to examine the probable effects of soy extract, containing the phytoestrog...