We present a three-stage probabilistic model for the progression of Chronic Myeloid Leukemia (CML), as manifested by leukemic stem cells, progenitor cells and mature cells. This is captured through process cell division mutation, with probabilities occurrence being assigned to both them. The key contributions this study include, determination expected number well total these (in terms probabili...

The fucose-binding lectin from Lotus tetragonolobus (FBII) has been previously shown to bind specifically to normal cells of the myeloid and monocytic lineages. The purpose of this study was to explore the utility of fluoresceinated FBI-I as a leukemia differentiation marker in conjunction with a panel of other frequently used surface markers (Fe receptor. HIA-DR. OKM1 . and antimonocyte antibo...

The graft-vs-tumor effect is an important part of the curative potential of allogeneic transplantation. We characterized the effect of transplanted donor mononuclear cells on relapse- and event-free survival after allogeneic bone marrow transplantation (BMT). We studied 113 consecutive patients with hematologic malignancies who received non-T-cell-depleted BMT from human leukocyte antigen (HLA)...

Tyrosine kinase inhibitors (TKIs) are the mainstay of current management chronic myeloid leukemia (CML) [1]. With introduction imatinib, many CML patients in phase (CML-CP) we...

OBJECTIVE To investigate the effects of lentivirus mediated STAT3 silencing on human chronic myeloid leukemia cells (K562) and the growth of chronic myeloid leukemia mice as well as to explore the potential mechanisms. METHODS Unbtreated K562 cells (CON), blank lentivirus transfected K562 cells (NC) and K562 cells expressing STAT3 siRNA (STAT3 siRNA) were injected into SCID mice to establish ...

BACKGROUND Incubation of chronic myeloid leukemia cells in hypoxia inhibits growth and selects BCR/Abl-independent cells with stem cell properties which are refractory to imatinib-mesylate. This study aimed to characterize the relationship of this refractoriness with glucose availability in the environment. DESIGN AND METHODS K562 or primary chronic myeloid leukemia cells were cultured at 0.1...

It has been shown previously that multilineage human hematopoiesis is maintained within human fetal bone marrow (BM) fragments implanted into severe combined immunodeficient (SCID) mice. We describe here an application of this animal model, the SCID-hu mouse, to the study of human myeloid leukemias. BM cells from 8 patients with various types of myeloid leukemias were injected directly into hum...