The “secondary effects” doctrine allows municipalities to zone, or otherwise regulate, sexually oriented businesses like strip clubs. Negative “secondary effects” (externalities) justify limiting First Amendment protection of speech conducted inside strip clubs. We utilize a repeat sales regression model of housing prices to estimate the causal effect of strip clubs on nearby residential proper...

The interaction of Cu(2+) and Ni(2+) with the N-terminal tail of histone H2B, the 31 amino acid peptide H2B(1-31) (Ac-PEPAKSAPAPKKG(13)SKKAVTKAQKKD(25)GKKRKR-NH(2)), studied by various spectroscopic techniques (UV/Vis, CD, EPR and NMR) are described. The results showed the formation of Cu(2+)-H2B(1-31) complexes above pH 7.3 most probably through the beta-carboxylate group of D25. With the incr...

PURPOSE Studies have suggested that male physicians earn more than their female counterparts. The authors examined whether this disparity exists in a recently hired cohort. METHOD In 2010-2011, the authors surveyed recent recipients of National Institutes of Health (NIH) mentored career development (i.e., K08 or K23) awards, receiving responses from 1,275 (75% response rate). For the 1,012 ph...

A toxin from the scorpion Tityus serrulatus (TsTX-Kalpha) blocks native squid K(+) channels and their cloned counterpart, sqKv1A, at pH 8 ((native)K(d) approximately 20 nM; (sqKv1A)K(d) approximately 10 nM). In both cases, decreasing the pH below 7.0 significantly diminishes the TsTX-Kalpha effect (pK = 6.6). In the cloned squid channel, the pH dependence of the block is abolished by a single p...

This paper argues that the sharing economy—through the use of the Internet and real time reputational feedback mechanisms—is providing a solution to the lemons problem that many regulators have spent decades attempting to overcome. Section I provides an overview of the sharing economy and traces its rapid growth. Section II revisits the lemons theory as well as the various regulatory solutions ...

Using a dataset of over 1.6 million inspections by the Occupational Safety and Health Agency (OSHA) from 1990 through 2010, we explore the determinants of inspection and enforcement outcomes. OSHA is an institutionally split agency, with the federal agency conducting inspections in 25 states and state agencies conducting inspections in the remaining 25. The geographic variety and range over 21 ...

Histones are modified post-translationally, e.g. by methylation of lysine and arginine residues, and by phosphorylation of serine residues. These modifications regulate processes such as gene expression, DNA repair, and mitosis and meiosis. Recently, evidence has been provided that histones are also modified by covalent binding of the vitamin biotin. The aims of this study were to identify biot...

This research was supported by the grants from the Massachusetts General Hospital Fund for Medical Discovery to T.S., from NIMH to G.K. & C.W. (K23 MH02034, MH071635-01, MH065356-03 ), from NARSAD and the Sidney Baer Trust to T. S. and G.K., and from NICHD to P.H. (HD25889), and by the Institute for Mental Illness and Neuroscience Discovery (MIND). Conclusion Our results suggest that in schizop...

PURPOSE To explore aspects of mentoring that might influence medical faculty career satisfaction and to discover whether there are gender differences. METHOD In 2010-2011, the authors surveyed 1,708 clinician-researchers who received (in 2006-2009) National Institutes of Health K08 and K23 awards, which provided mentoring for career development. The authors compared, by gender, the developmen...

This entry examines the relationship between property rights and environmental protection. According to the ‘tragedy of the commons’ model, environmental pollution and resource depletion result from the inadequate specification of property rights in environmental goods. Two solutions typically are offered for averting the ‘tragedy’: (1) specify property rights (that is, privatize the commons) o...