in this paper, a novel matched filter based on a new kernel function with cauchy distribution is introduced to improve the accuracy ofthe automatic retinal vessel detection compared with other available matched filter‑based methods, most notably, the methods builton gaussian distribution function. several experiments are conducted to pick the best values of the parameters for the new designedfi...

Magnesium is the most abundant divalent cation in living cells and is crucial to several biological processes. MgtE is a Mg(2+) channel distributed in all domains of life that contributes to the maintenance of cellular Mg(2+) homeostasis. Here we report the high-resolution crystal structures of the transmembrane domain of MgtE, bound to Mg(2+), Mn(2+) and Ca(2+). The high-resolution Mg(2+)-boun...

This paper presents a frequency domain degraded image restoration practical method. We call it practical wiener filter. Using this filter, the value for K parameter of wiener filter is determined experimentally that is so difficult and time consuming. Furthermore, there is no any absolute remark to claim that the obtained images by restoration process are the best could be possible. In order to...

This paper introduces a polyphase implementation and design of an oversampled K-channel generalized DFT (GDFT) filter bank, which can be employed for subband adaptive filtering, and therefore is required to have a low aliasing level in the subband signals. A polyphase structure is derived which can be factorized into a real valued polyphase network and a GDFT modulation. For the latter, an FFT ...

K(+) channels distinguish K(+) from Na(+) in the selectivity filter, which consists of four ion-binding sites (S1-S4, extracellular to intracellular) that are built mainly using the carbonyl oxygens from the protein backbone. In addition to ionic discrimination, the selectivity filter regulates the flow of ions across the membrane in a gating process referred to as C-type inactivation. A charac...

The ability of biological ion channels to conduct selected ions across cell membranes is critical for the survival of both animal and bacterial cells. Numerous investigations of ion selectivity have been conducted over more than 50 years, yet the mechanisms whereby the channels select certain ions and reject others are not well understood. Here we report a new application of Jarzynski's Equalit...

Although a few x-ray structures of the KcsA K(+) channel have been crystallized several issues concerning the mechanisms of the ionic permeation and the protonation state of the selectivity filter ionizable side chains are still open. Using a first-principles quantum mechanical/molecular mechanical simulation approach, we have investigated the protonation state of Glu-71 and Asp-80, two importa...