Abstract The global reach of the COVID-19 pandemic and ensuing localized policy reactions provides a case to uncover how crisis translates into linguistic discourse. Based on JSI Timestamped Web Corpora that are automatically POS-tagged accessible via SketchEngine, this study compares French, German, Dutch, English. After identifying main names used denote virus its disease, we extracted total ...

AZD6244 is a small molecule inhibitor of the MEK (MAP/ERK kinase) pathway currently in clinical trials. However, the mechanisms mediating intrinsic resistance to MEK inhibition are not fully characterized. To define molecular mechanisms of MEK inhibitor resistance, we analyzed responses of 38 lung cancer cell lines following AZD6244 treatment and their genome-wide gene expression profiles and i...

Purpose: The main purpose of the present study is to find comparative job satisfaction scores between different levels employees (foremen and workers). Design/Methodology/Approach: Researcher has selected sugar industrial sector Bangladesh as research ground. On basis stratified random sampling, 300 respondents have been from 5 (five) state-run mills. This absolutely based on primary sources in...

CMTM3 (CKLF-like MARVEL transmembrane domain containing 3) possesses tumor suppressor properties in multiple types of malignancies. Restoration of CMTM3 significantly inhibits the metastasis of gastric cancer, and its expression level is correlated with prognosis. However, the physiological effects and the mechanism of CMTM3 remain unknown. Here, we suppress CMTM3 expression by shRNA to explore...

[Qi2(L3)(3,5-prz)] (L3 = 1,3-bis(2-hydroxy-4-methoxybenzylideneamino)-propan-2-ol) (3) was synthesized and its crystal structure determined. The compound consists of discrete binu­ clear units, in which copper atoms are linked by the alkoxide oxygen atom of the ligand and the pyrazolate nitrogen atoms. Variable-temperature magnetic susceptibility measurements for a powdered sample of the comple...

Radiation therapy plays a central role in the treatment of glioblastoma, but it is not curative due to the high tumor radioresistance. Phosphatidyl-inositol 3-kinase/protein kinase B (Akt) and Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) pathways serve to block the apoptosis process, keeping cells alive in very toxic environments such as chemotherapy or ionizing...

Neurofibromatosis type 1 (NF1) is a common cancer predisposition syndrome in which affected individuals develop benign and malignant nerve tumors. The NF1 gene product neurofibromin negatively regulates Ras and mammalian target of rapamycin (mTOR) signaling, prompting clinical trials to evaluate the ability of Ras and mTOR pathway inhibitors to arrest NF1-associated tumor growth. To discover ot...