Mechanisms of CNS repair have vital medical implications. We show that traumatic injury to the ventral midline of the embryonic Drosophila CNS activates cell divisions to replace lost cells. A pilot screen analyzing transcriptomes of single cells during repair pointed to downregulation of the microtubule-stabilizing GTPase mitochondrial Rho (Miro) and upregulation of the Jun transcription facto...

Two questionnaires were developed for measuring disability due to juvenile rheumatoid arthritis (JRA), one based on patient reports and one on parent reports. These questionnaires were termed the Juvenile Arthritis Functional Assessment Report for Children (JAFAR-C) and for Parents (JAFAR-P). The questionnaires were administered to 72 JRA patients ages 7-18 years and to their parents. Responden...

Extremely hot days in Japan are known to persist for a week or more, and they measured by the temperature anomaly at 850 hPa averaged over derived from JRA-55 reanalysis data, denoted as T850JP. Severe high-temperature anomalies often accompanied multiple teleconnection patterns that affect weather Japan, but their relative contribution individual heat wave events has not yet been quantified. I...

The JR blood group system (ISBT 032) consists of one antigen,Jra, which is of high prevalence in all populations. The rare Jr(a-) phenotype has been found mostly in Japanese and other Asian populations, but also in people of northern European ancestry, in Bedouin Arabs, and in one Mexican. Anti-Jra has caused transfusion reactions and is involved in hemolytic disease of the fetus and newborn. T...

Juvenile rheumatoid arthritis (JRA) differs in many aspects from its adult counterpart (Edstrom, 1958); one of the differences is a low incidence of positive sero-reactions for rheumatoid factors (RF) in patients with JRA (Bywaters, Carter, and Scott, 1959; Sievers, Ahvonen, Aho, and Wager, 1963; Ansell, 1966). Although the agglutinating activity of RF was found in different classes of immunogl...

A previously pilot study of treatment with transfer factor in 3 patients with juvenile rheumatoid arthritis (JRA) gave promising results. However, in this small and open study no definite conclusions could be drawn. Therefore, a double-blind group trial was performed in 12 JRA patients treated with transfer factor, and in 12 placebo-treated control patients. The patients were evaluated clinical...

Juvenile rheumatoid arthritis (JRA) is one of the most common disabling rheumatic diseases in children in the pathogenesis of which play an important role certain subpopulations of lymphocytes. The functions of these immune cells are associated with the molecular receptors on their CD cellular membranes. The aim of the study was to study the state of molecular receptors of peripheral blood lymp...