Viral infection or TLR3 engagement causes activation of the transcription factors IRF-3 and NF-jB, which collaborate to induce transcription of type I IFN genes. IKKe and TBK1 are two IKK-related kinases critically involved in virusand TLR3-triggered activation of IRF-3. We identified a protein termed SIKE (for Suppressor of IKKe) that interacts with IKKe and TBK1. SIKE is associated with TBK1 ...

doi: 10.1111/cas.12571 Breast cancer is a leading cause of cancer-related death in women. Prolonged exposure to the ovarian hormones estrogen and progesterone increases the risk of breast cancer. Although estrogen is known as a primary factor in mammary carcinogenesis, very few studies have investigated the role of progesterone. Receptor activator for nuclear factor-jB (NF-jB) ligand (RANKL) pl...

Living cells must be capable of rapidly responding to intrinsic and environmental cues to ensure normal development and homeostasis. The NF-jB transcription factor mediates a series of such rapid-response programs, serving as a master regulator of gene transcription in cells subjected to inflammation, irradiation, or other stress states (Karin, 2009). While cells must be able to rapidly respond...

Jordan C*-algebras go back to Kaplansky, see [20]. Let J be a complex Banach Jordan algebra, that is, a complex Banach space with commutative bilinear product x◦y satisfying x◦(x2◦y) = x2◦(x◦y) as well as ||x◦y|| ≤ ||x||·||y||, Bounded symmetric domains and generalized operator algebras 51 and suppose that on J is given a (conjugate linear) isometric algebra involution x 7→ x∗. Then J is called...

We consider deterministic and disordered frustrated systems in which we can show some strict inequalities with respect to related ferromagnetic systems. A case particularly interesting is the Edwards-Anderson spin-glass model in which it is possible to determine a region of uniqueness of the Gibbs measure, which is strictly larger than the region of uniqueness for the related ferromagnetic syst...

By exploiting his recent results, the author further investigates the extent to which variation in the coefficients of a unitary convex decomposition of a vector in a unital JB∗-algebra permits the vector decomposable as convex combination of fewer unitaries; certain C∗-algebra results due to M. Rørdam have been extended to the general setting of JB∗-algebras.

Venous reflux in the internal jugular vein branches (JB) was found frequently in patients of certain neurologic disorders. We hypothesized that the retrograde-flow in JB is associated with retrograde hypertension transmitted from the internal jugular vein (IJV), which presumably underlies those neurologic disorders. In this study, we used color-Doppler imaging to evaluate the dynamic venous flo...

Invasive species' facilitation, or benefiting, of native species is rarely considered in biological invasion literature but could have serious economic consequences should a non-native herbivore facilitate injury by a native pest of high-value crops. Japanese beetle (JB), Popillia japonica, a polyphagous scarab, facilitates feeding by the obligate fruit-feeding native green June beetle (GJB), C...