Human scabies is caused by an infection of the skin by the human itch mite (Sarcoptes scabiei var. hominis). There are different medications for the treatment of scabies. This study aimed at comparing the efficacy and safety of oral ivermectin vs. sulfur 10% ointment for the treatment of scabies. In total, 420 patients with scabies were enrolled, and randomized into two groups: the first group ...

In areas co-endemic for loiasis and onchocerciasis, the classic Community-Directed Treatment using ivermectin (Mectizan(R)) must be adapted as additional program activities, better communication and tighter control of ivermectin stocks are required to minimize risk and manage serious adverse events following ivermectin treatment in patients co-infected with Loa loa. The importance of these seri...

Cochlioquinone A, isolated from the fungus Helminthosporium sativum, was found to have nematocidal activity. Cochlioquinone A is a competitive inhibitor of specific [3H]ivermectin binding suggesting that cochlioquinone A and ivermectin interact with the same membrane receptor.

Ivermectin was first approved for human use as an endectocide in the 1980s. It remains one of most important global health medicines history and has recently been shown to exert vitro activity against SARS-CoV-2. However, macrocyclic lactone family compounds not previously evaluated The present study aims at comparing their anti-viral relevant pulmonary cell lines vitro. Here, antiviral avermec...

Some studies show that ivermectin enhances the immune response in human and animals. An experimental model of broiler chickens was designed and developed using ivermectin to evaluate its immunomodulatory response at different doses. Experiment was done on macrophage engulfment percentage and the skin thickness in the broilers. They were divided into six major groups A through F, having ten broi...

The aim of the present study was to determine the efficacy of ivermectin against Cyathostominae infections and to describe the drug's pharmacokinetic parameters during two seasonal deworming treatments in horses. The study was performed on warm-blooded mares aged 3-12 years weighing 450-550 kg. A single bolus of an oral paste formulation of ivermectin was administered at a dose of 0.2 mg/kg BW ...

Onchocerciasis is an endemic disease in Ondo state, Nigeria. Community directed distribution of ivermectin is currently on-going in some local government areas of the state. Randomly selected persons (2331 males and 2469 females) were interviewed using a modified rapid assessment procedure for Loa loa (RAPLOA) to assess community directed treatment with ivermectin. The retrospective study evalu...

Ivermectin, a macrocyclic lactone, is commonly used against parasitic diseases in both animals and human beings. Although, its anti-parasitic activity is well known, there is dearth of literature on its effect on the host. The present study on biochemical effects of ivermectin in Wistar albino rats was undertaken to evaluate if it is toxic to the host ?. This investigation evaluated the effect ...

BACKGROUND Currently, the predominant onchocerciasis control strategy in Africa is annual mass drug administration (MDA) with ivermectin. However, there is a consensus among the global health community, supported by mathematical modelling, that onchocerciasis in Africa will not be eliminated within proposed time frameworks in all endemic foci with only annual MDA, and novel and alternative stra...

Pour-on formulations of endectocides are extensively used to treat and control systemic parasitic diseases in cattle, worldwide. The purpose of the present study was to investigate the influence of the natural licking behaviour of cattle on the plasma and faecal disposition of topically administered ivermectin. Twelve Holstein cattle were given one single intravenous (i.v.) (200 microg/kg) and ...