abstract introduction: frequency of tramadol intoxication is increasing as a result of its use as a drug for suppression of withdrawal symptoms by opioids abusers and its wide accessibility of this drug. tramadol intoxication can lead to death and, therefore, early identification of its clinical manifestations is crucial since early detection of the intoxication and its treatment could improve ...

tramadol is a synthetic analgesic of opioids which has more flexible mechanisms of action than typical opioids. since it has been reported in previous study that typical opioids like morphine can affect the bone homeostasis, it is worthwhile to examine the effects of tramadol on tooth movement. in this study we investigated effects of tramadol on orthodontic tooth movement in rats.30 male wista...

Tramadol is a novel centrally acting opioid analgesic used for the treatment of mild to severe pain. This drug is the most prescribed opioid worldwide. It has been approved as an analgesic in Iran since 2002. Unfortunately Tramadol dependency has become very common in Iran in various age groups and genders but in particular is abused among the young generation. Overdose of Tramadol is a well-kn...

BACKGROUND Tramadol hydrochloride (tramadol) is a synthetic opioid analgesic with a relatively weak affinity at opioid receptors. At analgesic doses, tramadol seems to cause little or no respiratory depression in humans, although there are some conflicting data. The aim of this study was to examine whether tramadol causes dose-dependent inhibitory effects on the ventilatory carbon dioxide respo...

Tramadol is a centrally acting analgesic selective for the μ-opioid receptor with antidepressant and dopamine releasing actions. In Egypt, dependence on and abuse of tramadol presents a challenging health problem and the drug is included in the narcotic analgesic schedule III. In this study, a sample of commercially available honey was brought to the laboratory of narcotics and poisons on the s...

BACKGROUND Butorphanol tartrate, a mixed synthetic agonistantagonist opioid analgesic has been used for management of postoperative pain in minor and major surgical procedures.(14,20) Tramadol hydrochloride is a centrally acting opioid which is effectively used in postoperative pain in various minor and major surgeries. MATERIALS AND METHODS Twenty subjects selected randomly received butorpha...

The development of combination therapy is a coherent approach in severe pain treatment. The present study investigated the antinociceptive effect of pregabalin alone and in combination with tramadol in acute pain modeling. Therefore, three groups of male mice received either pregabalin (1 to 400 mg/Kg), tramadol (10 to 80 mg/Kg) or their combination intraperitoneally. Then latency time, maximum...

BACKGROUND Tramadol-induced seizures might be pathologically associated with serotonin syndrome. Here, the authors investigated the relationship between serotonin and the seizure-inducing potential of tramadol. METHODS Two groups of rats received pretreatment to modulate brain levels of serotonin and one group was treated as a sham control (n = 6 per group). Serotonin modulation groups receiv...

Despite its structural similarity to codeine, tramadol is an unusual analgesic whose antinociceptive efficacy is not solely a result of opioid actions but also of its apparent capacity to block monoamine uptake. Tramadol is a mixture of stereoisomers. In this study, we have examined the actions of racemic, (+)- and (-)-tramadol, in addition to O-desmethyltramadol (the main human metabolite), on...

Neuropathic pain constitutes a serious therapeutic problem. In most cases polytherapy is necessary. Tramadol and antidepressants have common mechanisms of action and are frequently used together in clinical practice, thus interaction between them is very important. In the present study isobolographic analysis for equivalent doses of drugs was applied to examine the nature of interaction between...