Abstract The Fairlie-Gumbel-Morgenstern (FGM) family has been investigated in detail for various continuous marginals such as Cauchy, normal, exponential, gamma, Weibull, lognormal and others. It has been a popular model for the bivariate distribution with mild dependence. However, bivariate FGM’s with continuous marginals on a bounded support discussed in the literature are only those with uni...

OBJECTIVE Caspase-8 (CASP8) plays a central role in the apoptotic pathway and aberrant regulation of this pathway may cause cancers. Previous studies investigating the association between CASP8 -652 6N ins/del polymorphism and colorectal cancer (CRC) risk showed inconclusive results. We performed a meta-analysis of all available studies to investigate this association. METHODS All studies pub...

Abstract We give some adequate extension, in the framework of a general Lévy process, of our previous construction of processes with one-dimensional martingale marginals, done originally in the set-up of Brownian motion. The Lévy process framework allows us to streamline our previous arguments, as well as to reach a larger class of such processes, even in the Brownian case. We give some illustr...

Mammalian cells produce a variety of inositol phosphates (InsPs), including Ins(1,4,5)P3 that serves both as a second messenger and as a substrate for inositol polyphosphate kinases (IPKs), which further phosphorylate it. We report the structure of an IPK, the human Ins(1,4,5)P3 3-kinase-A, both free and in complexes with substrates and products. This enzyme catalyzes transfer of a phosphate fr...

When GPS blockage occurs for a loosely coupled GPS/INS system, its navigation error diverges. To deal with such cases, this paper introduces an integration scheme for GPS, INS, and an image sensor. The proposed integration scheme is attractive in that it accomplished the position and velocity accuracy improvement by the angular information only. The angular information is provided by the gimbal...

AT&T participated in two tasks at TRECVID 2011: contentbased copy detection (CCD) and instance-based search (INS). The CCD system developed for TRECVID 2010 was enhanced for speed and augmented with an additional picturein-picture detector and alternative audio features [1]. As a pilot task, participation in INS evaluated object-level contentbased copy detection and created a basis for integer-...

ion: The input term has the form "\x :: Dom D. e[x]" (x could be a pair). Add (x,D) to the database while parsing e[x] recursively, obtaining the result "(e’[x],E)". Return the pair ("lambda D(\x. e’[x])","cf(D,E)"). Strictly speaking, this is not a valid inference since a lambda abstraction need not be continuous just because it maps elements of its domain D to elements of its codomain E (see ...

T HE TECHNIC of spleisic aspirations has beets used ins over onse hunidred amid fifty cases at Kinsgs Coumst-y Hospital durinsg the past five years’ as ant aid to the diagusosis amsd study of hematologic disorders. Ins 1951 the enslarged spleems of ant unsdiagmsosed patietst was aspirated ausd fouusd to have 27 per ceust plasma-myeloma cells. The diagntosis of multiple myeloma was subsequemstly...

Antibodies against Ins(1,4,5)P3 were raised by immunizing rabbits with two types of InsP3-BSA conjugates which were synthesized by covalently coupling Ins(1,4,5)P3 to the carrier protein via alkyl linkages. The anti-Ins(1,4,5)P3 antibody was detected by a novel ELISA using Ins(1,4,5)P3-immobilized microtitre plates. Both antiserum preparations showed specific binding with Ins(1,4,5)P3, with tit...

The role of Ca2+ in the generation of inositol phosphates was investigated using rat pancreatic islets after steady state labeling with my0-[2-~H]inositol. Depolarizing K+ concentrations (24 mM) evoked early ( 2 s) increases in inositol 1,4,5-trisphosphate (Ins1,4,5-P,) and inositol 1,3,4,5-tetrakisphosphate (Ins1,3,4,5-P4) as measured by high performance anionexchange chromatography. The incre...