Spinal Muscular Atrophy is caused by homozygous loss of SMN1. All patients retain at least one copy of SMN2 which produces an identical protein but at lower levels due to a silent mutation in exon 7 which results in predominant exclusion of the exon. Therapies targeting the splicing of SMN2 exon 7 have been in development for several years, and their efficacy has been measured using either in v...

Information systems security (ISS) has become one of the top agendas of companies located in the developed world. Despite this fact, there is an increasing trend in the types and frequency of ISS breaches. Most of the time researchers and practitioners focus on threat that are caused by external agents while most of the threats are originated from insiders. In addition to this, the majority of ...

The attenuation of sedimentation and convection in microgravity can sometimes decrease irregularities formed during macromolecular crystal growth. Current terrestrial protein crystal growth (PCG) capabilities are very different than those used during the Shuttle era and that are currently on the International Space Station (ISS). The focus of this experiment was to demonstrate the use of a comm...

Input-to-state stability (ISS) of a feedback interconnection of two discrete-time ISS systems satisfying an appropriate small gain condition is investigated via the Lyapunov method. In particular, an ISS Lyapunov function for the overall system is constructed from the ISS Lyapunov functions of the two subsystems. We consider parameterized families of discretetime systems that naturally arise wh...