peptaibols in microbial culture extracts3~5). Here we report the isolation and structure elucidation of peptaibolin (1, Fig. 1) as an unusual representative of the peptaibol family of lipophilic antibiotics. 1 was disclosed in two fungal strains, Sepedonium sp. HKI-0117 and Sepedonium ampullosporum HKI-0053 coproducing the neuroleptic peptaibol-type antibiotic ampullosporin5). In contrast to th...

In the course of studies on biologically active substances from pathogenic microorganisms, a new antibiotic SO-75R1 was isolated from the mycelium of Nocardia brasiliensis IFM 075. This paper describes the fermentation, isolation and structural elucidation of SO-75R1. The seed broth was prepared by inoculating mycelial elements of the producing strain (IFM 075) grown on Sabouraud dextrose agar ...

Garciniavalline (1), a novel aporphinoid alkaloid, in addition to four known alkaloids,cleistopholine (2), O-methylmoschatoline (3), (-)-oliveroline (4) and (-)-oliveridine (5), wereisolated and characterized from Garcinia Parvifolia Miq. stem bark. Structural elucidation ofthese compounds was established by spectroscopic methods. Among them, alkaloids (2) and (4)exhibited antiplasmodial activi...