نتایج جستجو برای: islet

تعداد نتایج: 17355  

Journal: :Proceedings 2007
Shinichi Matsumoto Hirofumi Noguchi Bashoo Naziruddin Nicolas Onaca Andrew Jackson Hatanaka Nobuyo Okitsu Teru Kobayashi Naoya Göran Klintmalm Marlon Levy

Pancreatic islet transplantation is a promising treatment for diabetes but still faces several challenges. Poor islet isolation efficiency and poor long-term insulin independence are currently two major issues, although donor shortage and the need for immunosuppressants also need to be addressed. We established the Kyoto islet isolation method (KIIM), which has enabled us to isolate and transpl...

Journal: :Diabetes 2005
Michael R Rickels Mark H Schutta Rebecca Mueller James F Markmann Clyde F Barker Ali Naji Karen L Teff

Islet transplantation can eliminate severe hypoglycemic episodes in patients with type 1 diabetes; however, whether intrahepatic islets respond appropriately to hypoglycemia after transplantation has not been fully studied. We evaluated six islet transplant recipients, six type 1 diabetic subjects, and seven nondiabetic control subjects using a stepped hyperinsulinemic-hypoglycemic clamp. Also,...

Journal: :The American journal of physiology 1998
P O Carlsson A Andersson L Jansson

This study aimed to elucidate possible age-related changes in islet blood perfusion in lean and obese C57BL/6 mice. Obese mice aged 1 mo were hyperglycemic and hyperinsulinemic and had an increased islet blood flow compared with age-matched lean mice. This augmented blood flow could be abolished by pretreatment with leptin. The islet blood perfusion was, in contrast to this, markedly decreased ...

Journal: :The Journal of clinical investigation 1994
Y Liang S Bonner-Weir Y J Wu C D Berdanier D K Berner S Efrat F M Matschinsky

The present study evaluated the involvement of glucose transport and phosphorylation in glucose-stimulated insulin release from pancreatic islets. Using quantitative histochemical techniques, we investigated basal islet glucose content, islet glucose uptake in situ during acute extreme experimental hyperglycemia, and islet glucokinase activity in several animal models of diabetes and obesity. T...

Journal: :Cell transplantation 2009
John C Stendahl Dixon B Kaufman Samuel I Stupp

Intrahepatic islet transplantation provides a potentially more benign alternative to pancreatic transplantation. However, islet transplants are associated with limited engraftment potential. This inefficiency is likely at least partially attributable to the isolation process, which removes islets from their native environment. Isolation not only disrupts the internal vascularization and innerva...

Journal: :Endocrinology 1997
A Y Grupping M Cnop C F Van Schravendijk J C Hannaert T J Van Berkel D G Pipeleers

Abnormalities in lipoprotein metabolism are common in diabetes. It is unknown whether variations in form or concentration of lipoproteins influence the function of pancreatic beta cells. This study investigates whether low density lipoproteins (LDL) exhibit specific interactions with islet beta cells. Radioactively labeled LDL (125I-LDL) and fluorescently labeled LDL (DiI-LDL) were used as trac...

2013
Zhongsu Yu Juanjuan Kong Bo Pan Huichao Sun Tiewei Lv Jing Zhu Guoying Huang Jie Tian

OBJECTIVE Islet-1 is an important transcription factor for cardiac development through mediating extensive interactions between DNA and proteins. The present study was to investigate the role of Islet-1 in regulating the expression of cardiac development-related transcription factors and mechanism. METHODS AND RESULTS The expression of Islet-1 and histone acetylases (HATs) subtype p300 was de...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Rayner Rodriguez-Diaz Stephan Speier Ruth Damaris Molano Alexander Formoso Itai Gans Midhat H Abdulreda Over Cabrera Judith Molina Alberto Fachado Camillo Ricordi Ingo Leibiger Antonello Pileggi Per-Olof Berggren Alejandro Caicedo

The autonomic nervous system is thought to modulate blood glucose homeostasis by regulating endocrine cell activity in the pancreatic islets of Langerhans. The role of islet innervation, however, has remained elusive because the direct effects of autonomic nervous input on islet cell physiology cannot be studied in the pancreas. Here, we used an in vivo model to study the role of islet nervous ...

Journal: :Cell transplantation 1996
C Ricordi N Murase C Rastellini R Behboo A J Demetris T E Starzl

We have tested the effect of donor bone marrow cell (DBMC) infusion on the survival of pancreatic islet allografts in the rat, without the use of cytoablative recipient conditioning. Lewis and diabetic Brown Norway rats were used as donors and recipients, respectively. Donor islets were placed beneath the left renal capsule. Infusion of DBMC and temporary immunosuppression followed by delayed i...

2013
Chunhua Dai Marcela Brissova Rachel B. Reinert Lara Nyman Eric H. Liu Courtney Thompson Alena Shostak Masakazu Shiota Takamune Takahashi Alvin C. Powers

Pancreatic islets adapt to insulin resistance through a complex set of changes, including β-cell hyperplasia and hypertrophy. To determine if islet vascularization changes in response to insulin resistance, we investigated three independent models of insulin resistance: ob/ob, GLUT4(+/-), and mice with high-fat diet-induced obesity. Intravital blood vessel labeling and immunocytochemistry revea...

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