introduction: anesthetic agents, blood pressure, arterial ph and blood gases have found to influence on the pathophysiology of experimental stroke. despite, there are very few comparative studies about effects of anesthetic agents in animal model of cerebral ischemia. therefore, in this study, we investigated the effects of chloral hydrate and pentobarbital anesthesia, as comparative study, on ...

purpose: to compare ophthalmic artery velocity in eyes with nonarteritic anterior ischemic optic neuropathy (naion) with that of normal fellow eyes. methods: in this case-control study, 20 patients with unilateral naion and disease onset less than 8 weeks, were enrolled. using color doppler imaging, mean, maximum systolic and end diastolic ophthalmic artery velocities were evaluated. the result...

background: clopidogrel is a standout amongst the most ordinarily recommended medications to avoid ischemic occasions taking after coronary disorder or stant position. however, impaired responses the therapy as well as resistance to the therapy have also been reported. genetic variants play an important role in clopidogrel biotransformation of its active metabolite that may subsequently influen...

objective(s):every year, a large number of people lose their lives due to stroke. stroke is the second leading cause of death worldwide. surprisingly, recent studies have shown that preconditioning with hyperoxia (ho) increases tissue tolerance to ischemia, ultimately reducing damages caused by stroke. addressed in this study are beneficial contributions from ho preconditioning into reduced har...

background: although the issue of hyperuricemia as a risk factor for cardiovascular diseases (cvd) has been disputed, sev­eral studies have shown an association between hyperuricemia and   several cvd risk factors. the aim of this study was to assess distribution of uric acid level in yazd city, center of iran, and its association with cvd risk factors. methods: from autumn 2004 to summer 2005,...

changes in extra and intracellular neurotransmitter amino acids concentration in the early stage of acute cerebral ischemia have been reported. in this the study, serum level of gamma aminobutyric acid (gaba) and l-arginine in acute ischemic stroke patients was assessed. 60 patients with acute ischemic stroke and sixthy healthy volunteers as a control group were assessed. serum gaba was measure...

objectives the current study aimed to estimate the prevalence of ihd in the families of children with kd. patients and methods sixty-one children with kawasaki disease were admitted from december 21, 2004 to january 21, 2008to mofid children hospital (from one month to thirteen-year old) and 50 patients entered the study. subjects were divided into the severe (24subjects) and non-severe (26 sub...

objective: ischemic preconditioning (ipc) is an endogenous phenomenon that can induce ischemic tolerance (it) in variety of organs such as brain. in this study, we examined the intermittent and prolonged normobaric hyperoxia (ho) on neurologic deficit scores, infarct volume, and superoxide dismutase activity. materials and methods: the rats were divided to four main groups. first two main grou...

a number of evidences suggest that during ischemic stroke, serum iron and hemoglobin (hb) levels are changed. yet, there are few reports in the literature related to this issue and resolution of this mechanism requires further experiments. the aim of the present study was to investigate the potential role of serum iron and hemoglobin levels as a  biomarker in diagnosis of acute ischemic stroke....

background: the role of renin angiotensin system (ras) in ischemic/reperfusion (i/r) injuries is not fully elucidated. furthermore, it is not clear whether inhibition of ras by angiotensin-converting enzyme (ace) inhibitors has beneficial effects in terms of protecting the brain from i/r injuries. in this study enalapril is used as an ace inhibitor to evaluate the role of ras in i/r injuries in...