Virtually all cells exhibit metabolic flexibility and are capable of shifting their reliance on glycolysis relative to mitochondrial respiration. Such shifts can occur at different timescales through a variety of mechanisms, allowing cells to cope with prevailing nutrient availability or energetic demands. There is mounting evidence of the therapeutic potential of targeting such shifts. For exa...

CORONARY HEART DISEASE is the leading cause of death in the Western world and represents one of the major burdens on healthcare systems today. Targeting those strategies that limit the damage sustained as a result of a lethal ischemic insult has been a major goal for many years. One of these strategies, termed ischemic preconditioning, in which brief nonlethal episodes of ischemia protect the m...

CORONARY HEART DISEASE is the leading cause of death in the Western world and represents one of the major burdens on healthcare systems today. Targeting those strategies that limit the damage sustained as a result of a lethal ischemic insult has been a major goal for many years. One of these strategies, termed ischemic preconditioning, in which brief nonlethal episodes of ischemia protect the m...

abstract   objective: to evaluate and review our experience with pediatric spinal injuries and factors affecting outcome, the authors conducted a retrospective clinical study of 43 cases (32 boys, 11 girls) of pediatric spine injuries treated during four years (january 1999 to december 2003).   methods: forty-three children with spinal injuries were studied retrospectively over four years and w...

objectives the aim of this study was to obtain the epidemiology of this type of injury in tabriz imam reza hospital as a referral center in northwest of iran during 2009 to 2012. materials and methods one hundred bicycle-related patients during the three years were entered in this descriptive cross-sectional study. patient’s demographics, place and time of crash, mechanism of trauma, helmet and...

CORONARY HEART DISEASE is the leading cause of death in the Western world and represents one of the major burdens on healthcare systems today. Targeting those strategies that limit the damage sustained as a result of a lethal ischemic insult has been a major goal for many years. One of these strategies, termed ischemic preconditioning, in which brief nonlethal episodes of ischemia protect the m...

background: injury is a leading cause of morbidity and mortality in children. there is insufficient data on the epidemiology or incidence of injuries in the first two years of life, especially in iran. the main objective of this study was to describe the incidence and causes of injuries in a sample group of infants and toddlers in mashhad, iran. methods: this prospective, observational study, w...

Remote postconditioning (RPost) has a great therapeutic potential for protecting the myocardium during ischemiareperfusion in clinical practice. At same time, an important problem limiting use of conditioning effects clinic is presence metabolic disorders patient. The aim this work was to assess effect induced syndrome (iMetS) on efficacy infarct-limiting remote ischemic rats and study mechanis...

For us neonatologists, research about necrotizing enterocolitis always incites great curiosity, because our understanding of its physiopathology is largely speculative, and this illness haunts the neonatal intensive care unit. Nowadays, as viability increases, the prevalence of necrotizing enterocolitis is becoming more important because we are taking care of more immature and lower birth-weigh...