Fibrinogen γ' (γ') is a natural isoform of fibrinogen, and alters the rate of formation and the properties of clots. It could therefore affect outcome after ischaemic stroke. The prognostic significance of γ' fibrinogen levels is, however, still unclear. It was the objective of this study to assess levels of γ' in ischaemic stroke, and its association with short-term outcome. We included 200 is...

The mortality from ischaemic heart disease was studied in a prospective cohort of 1725 shipyard workers exposed to asbestos. The analyses were stratified for age and smoking habits and restricted to men. In agreement with other findings, men with impaired lung function had a significantly higher risk (relative risk (RR) = 3.5) of dying from ischaemic heart disease than men with normal lung func...

BACKGROUND Risk factors for arterial stroke in children include congenital heart malformations, vasculopathies, infectious diseases, collagen tissue diseases, and metabolic disorders. Results of previous case-control studies have shown an association between ischaemic stroke and hereditary prothrombotic risk factors: factor V G1691A and factor II G20210A mutations, raised lipoprotein (a), and d...

OBJECTIVES To assess the relationship between haematocrit and risk of major ischaemic heart disease events. DESIGN Prospective study of a cohort of men followed up for 9.5 years. SETTING General practices in 24 towns in England, Wales, and Scotland (British Regional Heart Study). SUBJECTS Altogether 7735 men aged 40-59 years at screening, who were selected at random from one general pract...

1. Introduction changes were unknown at that time, but Holland and Brooks in several papers emphasised that ST segment Following the pioneering studies of Julian [1] and Lown changes are influenced by both spatial and non-spatial and coworkers [2], demonstrating that ventricular fibrilla-factors [8–10]. Important spatial factors included the tion is common in patients with acute ischaemia, with...

In a recent study of ischaemic and post-ischaemic paraesthesiae in the upper limb (Poole, 1956a) it was noted that the responses in subjects with advanced motor neurone disease differed from those in normal subjects. This observation seemed relevant to the study both of motor neurone disease itself, and of factors which determine the production of paraesthesiae in normal and other diseased stat...

1. Ischaemic brain injury is a leading cause of death and disability in many countries. However, the pathological mechanisms underlying ischaemic brain injury, including oxidative stress, calcium overload, excitotoxicity and neuronal apoptosis, are perplexing and this makes it difficult to find effective novel drugs for the treatment of the condition. 2. Recently, gaseous molecules such as nitr...

AIMS Benefit from exercise training in heart failure has mainly been shown in men with ischaemic disease. We aimed to examine the effects of exercise training in heart failure patients < or = 75 years old of both sexes and with various aetiology. METHODS AND RESULTS Fifty-four patients with stable mild-to-moderate heart failure were randomized to exercise or control, and 49 completed the stud...

OBJECTIVES Ischaemic stroke is a frequent heterogeneous multifactorial disease that is affected by a number of genetic mutations and environmental factors. We hypothesised the clinical importance of the interactions between common, unfavourable genetic mutations and clinical risk factors in the development of ischaemic stroke. METHODS The Factor V Leiden G1691A (Leiden V), the prothrombin G20...