Only a few drugs are available for treating sleeping sickness and nagana disease; parasitic infections caused by protozoans of the genus Trypanosoma in sub-Saharan Africa. There is an urgent need for the development of new medicines for chemotherapy of these devastating diseases. In this study, three newly designed thiosemicarbazone iron chelators, TSC24, Dp44mT and 3-AP, were tested for in vit...

There is persuasive epidemiological evidence that regular intake of dietary bioactive polyphenolic compounds promotes human health. Because dietary polyphenolic compounds have a wide range of effects in vivo and vitro, including chelation of metals such as iron, it is prudent to test whether the regular consumption of bioactive polyphenolic components impair the utilization of dietary iron. We ...

Rober to Millini and Horst Kisch* Max-Planck-Institut für Strahlenchemie, D-4330 Mülheim, W.-Germany Carl Krüger Max-Planck-Institut für Kohlenforschung, D-4330 Mülheim, W.-Germany Dedicated to Professor Dr. Dr. h. c. mult. Günther Wilke on the occasion of his 60th birthday Z. Naturforsch. 40b, 187-192 (1985); received October 15, 1984 Diazepinones, Diazenes, Alkynes, Carbonyl-Iron Assistance B...

Understanding the management of iron in the brain is of great importance in the study of neurodegeneration, where regional iron overload is frequently evident. A variety of approaches have been employed, from quantifying iron in various anatomical structures, to identifying genetic risk factors related to iron metabolism, and exploring chelation approaches to tackle iron overload in neurodegene...

Polyphenol prevention of iron-mediated DNA damage occurs primarily through iron binding. Once bound, iron in the Fe(2+)-polyphenol complex autooxidizes to Fe(3+) in the presence of O(2). To determine the correlation between the rate of Fe(2+)-polyphenol autooxidation and polyphenol antioxidant ability, kinetic studies at pH = 6.0 in the presence of oxygen were performed using UV-vis spectrophot...

The regulation of Ca in human body is performed by Ca-ATPase. The affinity of erythrocyte plasma membrane Ca-ATPase (PMCA) was examined for three different porphyrin compounds, Tetraphenylporphinesulfonate (TPPS), 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) Chloride (FeTPPS) and 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) nitrosyl Chloride (FeNOTPPS), by en...

After growth of representatives of eight genera in the order Actinomycetales and two others related taxonomically to Mycobacterium under iron-deficient conditions, the following compounds were found in the media : salicylic and phenylacetic acids, but no mycobactin, with Thermoactinomyces vulgaris; 2,3dihydroxybenzoic acid with Corynebacterium equi, Mycococcus sp., Nocardia opaca and Streptospo...

The article deals with coordination compounds of iron(II) that may exhibit thermally induced spin transition, known as spin crossover, depending on the nature of the coordinating ligand sphere. Spin transition in such compounds also occurs under pressure and irradiation with light. The spin states involved have different magnetic and optical properties suitable for their detection and character...

Detecting harmful bioactive compounds produced by bloom-forming pelagic algae is important to assess potential risks to public health. We investigated the application of a cell-based bioassay: the rainbow trout gill-w1 cytotoxicity assay (RCA) that detects changes in cell metabolism. The RCA was used to evaluate the cytotoxic effects of (1) six natural freshwater lake samples from cyanobacteria...