We reviewed cardiac T2* assessments from 77 thalassemia major patients between the ages of 2.5 and 18 years to study optimal timing of cardiac iron screening by magnetic resonance imaging. No patient under 9.5 years of age showed detectable cardiac iron in contrast to 36% of patients between the ages of 15-18 years old, corresponding to an odds-ratio of 1.28 (28%) per year. All patients with ca...

introduction: it is generally assumed that 50% of the cases of anemia are due to iron deficiency. the most severe consequence of iron depletion is iron deficiency anemia (ida), and it is still considered the most common nutrition deficiency worldwide. the main risk factors for ida include: inadequate iron intake, impaired absorption or transport, physiologic losses associated with chronological...

BACKGROUND Iron has been implicated in the pathogenesis of various disorders. Mutations in the HFE gene are associated with an increase in serum iron parameters. The aim of this study was to estimate the heritability in serum iron parameters explained by HFE. METHODS Ninety families (980 subjects) were included in the present analysis. Heritability estimation was conducted using the variance ...

Disease in Childhood, 49, 386. Iron status of preterm low birthweight infants and their response to oral iron. The iron status of a group of preterm low birthweight infants preventively treated with oral iron has been studied by measuring haemoglobin concentration, serum iron concentration, and total iron binding capacity (TIBC) at intervals from birth to 9 months. 47 infants born at an average...

Mechanisms of brain and retinal iron homeostasis have become subjects of increased interest after the discovery of elevated iron levels in brains of patients with Alzheimer's disease and retinas of patients with age-related macular degeneration. To determine whether the ferroxidase ceruloplasmin (Cp) and its homolog hephaestin (Heph) are important for retinal iron homeostasis, we studied retina...

Iron deficiency is recognized as a significant health concern for women of childbearing age in the civilian population. In the military, most women are of childbearing age. Not only do they carry the normal risks for developing iron deficiency, but they also have the added threats of possible decreased choices of food high in iron content, increased physical activity, and weight loss. This can ...

a number of evidences suggest that during ischemic stroke, serum iron and hemoglobin (hb) levels are changed. yet, there are few reports in the literature related to this issue and resolution of this mechanism requires further experiments. the aim of the present study was to investigate the potential role of serum iron and hemoglobin levels as a  biomarker in diagnosis of acute ischemic stroke....

OBJECTIVE To describe the epidemiology of iron, zinc and iodide deficiencies in a probabilistic sample of Mexican women and children and explore its association with some dietary and socio-demographic variables. MATERIAL AND METHODS We carried out in 1999 an epidemiological description of iron (percent transferrin saturation, PTS, < 16%), serum zinc (< 65 ug/dl) and iodide (< 50 ug/l urine) d...

Identification of biological mediators in sarcopenia is pertinent to the development of targeted interventions to alleviate this condition. Iron is recognized as a potent pro-oxidant and a catalyst for the formation of reactive oxygen species in biological systems. It is well accepted that iron accumulates with senescence in several organs, but little is known about iron accumulation in muscle ...