Chronic sinusitis is a major cause of morbidity today. Regional variations in the incidence of this disease have been reported. The aim of this study was to evaluate the incidence of fungal infection as the causative agent of chronic sinusitis among Iranian patients. A cross sectional hospital based study was designed; the patients underwent paranasal sinus washing and maxillary sinus biopsy. A...

PURPOSE To investigate the role of MYOC and CYP1B1 in Iranian juvenile open angle glaucoma (JOAG) patients. METHODS Twenty-three JOAG probands, their available affected and unaffected family members, and 100 ethnically matched control individuals without history of ocular disease were recruited. Clinical examinations of the probands included slit lamp biomicroscopy, intraocular pressure (IOP)...

BACKGROUND Early diagnosis of tuberculosis (TB) is a major key for effective TB program. Evaluation of delay in diagnosis of smear positive TB is needed to evaluation of TB program situation in each country. The aim of this study was to evaluate of diagnosis delay in smear positive tuberculosis patients in Islamic Republic of Iran. MATERIALS AND METHODS In this cross sectional study, all smea...

OBJECTIVE To determine the warfarin maintenance dose in Iranian patients. METHODS This multicenter study was conducted between January 2007 and January 2008 in 5 different large cities of Iran. Patients older than 12 years receiving warfarin were included. During the first days of warfarin use, international normalized ration (INR) was measured daily and after that every 1-2 weeks, with a dur...

OBJECTIVES To determine the spectrum of mutations in the Mediterranean fever gene (MEFV) of Iranian Jews with familial Mediterranean fever (FMF) and to analyse their clinical manifestations. METHODS FMF patients with both parents of Iranian-Jewish (IJ) extraction or with one IJ parent (IJ-other, 10 of each) were characterized for clinical manifestations, and the B30.2 (PRYSPRY) domain of thei...

BACKGROUND Chronic pain can be associated with limitations in patient function. Assessment of pain-related limitations is one of the important outcome domains that should be considered when designing chronic pain clinical trials. Although a validated instrument for the assessment of pain-related disability in Iranian chronic low back pain (CLBP) patients exists, to date there is no psychometric...

AIM To investigate whether an AFF1 polymorphism was associated with susceptibility and clinical features of SLE in Iranian patients. METHODS A total of 320 patients with SLE and 330 age, sex and ethnically matched healthy control subjects were enrolled in the present study. Both cases and healthy controls were genotyped for rs340630 polymorphism located inside the AFF1using Amplification Refr...

BACKGROUND Hematopoietic stem cell transplantation is a potential cure for a range of life-threatening diseases, but is also associated with a high mortality rate. Nurses encounter a variety of situations wherein they are faced with discussing bad news with hematopoietic stem cell transplantation patients. RESEARCH OBJECTIVE The aim of this study was to explore the experiences and strategies ...

Background: It is well recognized that different patients respond in different ways to medications. The inter-individual variations are greater than the intera-individual variations, a finding consistent with the notion that inheritance is a determinant of drug responses. The recent identification of genetic polymorphisms in drug-metabolizing enzymes and drug transporters led to the hypothesis ...

INTRODUCTION Despite the importance of quality of life (QOL) in outcomes of cancer pa-tients, there have been a few Iranian studies investigating the Iranian patients' quality of life. The present study aimed to assess the cancer patients' QOL and its related factors. METHODS This cross-sectional study conducted in Shahid Ghazi Tabatabaei Hospital affiliated to Tabriz University of Medical Sc...