This study compares the EPID dosimetry algorithms of two commercial systems for pretreatment QA, and analyzes dosimetric measurements made with each system alongside the results obtained with a standard diode array. 126 IMRT fields are examined with both EPID dosimetry systems (EPIDose by Sun Nuclear Corporation, Melbourne FL, and Portal Dosimetry by Varian Medical Systems, Palo Alto CA) and th...

High dose rate (HDR) brachytherapy is one of the accepted treatment modalities in gastro-intestinal tract and bladder carcinomas. Considering the shortcoming of contact brachytherapy routinely used in gastrointestinal tract in treatment of big tumors or invasive method of bladder treatment, an intraluminal applicator with the capability of insertion into the tumor depth seems to be useful. This...

Theoretical and experimental studies have been applied for dosimetric parameters determination of the brachytherapy sources (1-3). Usually, Monte Carlo method has been used to define such quantities as the anisotropy dose function, the radial dose function, and the dose calculation close to the source in brachytherapy (4-6). Ir source is used widely in brachytherapy to treat localized tumors ne...

background: monte carlo and experimental relative dose determination in a water phantom, due to a high dose rate (hdr) 192ir source is presented for real energy spectrum and monochromatic at 356 kev. materials and methods: the dose distribution has been calculated around the 192ir located in the center of 30 cm ×30 cm ×30 cm water phantom using mcnp4c code by monte carlo method. relative dose v...

Adjuvant therapy of differentiated thyroid cancer with radioactive iodine ((131)I) is a standard procedure for the ablation of remnant thyroid tissue following surgery and for the treatment of iodine-avid metastases. Presently, there are two dosimetric concepts for the treatment of thyroid cancer using radioiodine: a) the bone marrow dose limited approach and b) lesion-based dosimetry. Both con...

BACKGROUND To assess the relationship between dosimetric parameters and the quality of life (QL) outcomes of patients with low-intermediate-risk localised prostate cancer (LPC) treated with low-dose-rate brachytherapy (LDR-BT). MATERIALS AND METHODS We evaluated the participants in two consecutive prospective studies of the QL of patients treated with LDR-BT for LPC. QL was evaluated by means...

PURPOSE To evaluate in a multicenter setting the ability of centers to perform pre-implant permanent prostate brachytherapy planning, fulfilling dosimetric goals and constraints based on the Groupe de Curiethérapie-European Society for Radiotherapy and Oncology guidelines in the setting of implantation after prior prostate transurethral resection (TURP). MATERIAL AND METHODS A reference trans...

Boron neutron capture therapy (BNCT) is a form of chemically targeted radiotherapy that utilises the high neutron capture cross-section of boron-10 isotope to achieve a preferential dose increase in the tumour. The BNCT dosimetry poses a special challenge as the radiation dose absorbed by the irradiated tissues consists of several dose components with different relative biological effectiveness...

Male Wistar rats were exposed to radon and its progeny (0.0, 60, 262 and 564 working level months, WLM), and the frequency of micronuclei was determined in deep lung fibroblasts, and deep lung, trachea and nasal epithelial cells with slopes of 0.28, 0.67, 0.34 and 0.11 micronuclei/1000 binucleated cells/WLM respectively. Micronuclei in deep lung fibroblasts, isolated and cultured using two meth...

Modern radiation techniques aim on improved 3-dimensional (3D) spatial selectivity of the dose application sparing dose from organs-at-risk (e.g. IMRT with micro-multileaf collimation, γ-knife-, Brachyand heavy-ion therapy). The corresponding 3D-dose distributions exhibit high dose gradients above 4 Gy/mm, which are difficult to be investigated using standard single-point dosimetric detectors ...