The intravascular administration of the ionic radiocontrast agent sodium iothalamate (2.9 g of iodine/kg body wt) to rats induced an increase in plasma concentration of immunoreactive endothelin from 21.3 +/- 1.2 to 36 +/- 3 fmol/mL, preceded by a transient rise in the plasma level of atrial natriuretic peptide and associated with a fall in RBF. Equi-iodine amounts of the nonionic agents ioxagl...

A prospective, randomized, double-blind comparative study of 200 patients was made to examine the image quality, safety, and costs of 100 ml of ioversol-320 (32 g iodine) and 150 ml of iohexol-300 (45 g iodine) in patients undergoing cranial CT. We found no statistically significant difference in image quality between the two low-osmolality, nonionic contrast agents at these doses. There was a ...

The degradation of seven compounds which are usually recalcitrant in classical activated sludge treatment (e.g., diclofenac, propranolol, iopromide, iohexol, iomeprol tebuconazole and propiconazole) was studied in a biofilm reactor (slow sand filtration). This reactor was used to treat real effluent-wastewater at different flow rates (hydraulic loadings) under aerobic conditions so removal and ...

To prepare lomustine-iohexol compound liposomes, and evaluate the properties, determine the entrapment efficiency. Liposomes were prepared by reverse evaporation method; orthogonal design was used to optimize the formulation. Free drugs and liposomes were separated using protamine aggregation method and entrapment efficiency was determined by HPLC. The optimal formula was as follows: soybean ph...

Myelography was performed in 16 monkeys using either metrizamide or iohexol, a new nonionic aqueous contrast medium. Eight of the animals received almost five times the recommended clinical dose of contrast medium per unit of body weight; the other eight received the equivalent of a high clinical dose. The severity of resultant arachnoiditis 12 weeks later was evaluated by repeat myelography an...

Abstract Objectives To determine the most preferable endoluminal contrast agent among mannitol, polyethylene glycol (PEG), iohexol, and water by comparing various qualitative (distension, fold visibility, homogeneity) quantitative parameters (distension) along with artifacts patient feedback for computed tomography enterography (CTE). Methods This was a prospective study including 120 patients ...