Cervical cancer emerges from cervical intraepithelial neoplasia (CIN) induced by high-risk HPV (HR-HPV) infections. However, the vast majority of CIN lesions regresses spontaneously, and only a few lesions persist or progress to invasive carcinoma. On the basis of morphological criteria, it is not possible to differentiate high-grade lesions that will regress or persist from those that inevitab...

BACKGROUND We investigated the effect of Pap smear screening on the incidence of invasive cancer of the cervix in the Western Cape, South Africa where screening is limited. METHODS Data were derived from a case-control study of the association of hormonal contraceptives and invasive cervical cancer. Incident cases (n = 524) of invasive cervical cancer who presented at two tertiary hospitals a...

Cervical cancer is a progressive disease with an onset of one to two decades on average. During the productive replication stage, the Human papillomavirus (HPV) genome is maintained episomally in the infected cervical epithelium and early gene products, including E5, are expressed. Therefore, E5 has a potential to contribute to the HPV-associated carcinogenic process. In invasive malignancies, ...

a 49 year old woman diagnosed as a cervical cancer patient, after receiving appropriate treatment experienced metastasis in her abdominopelvic cavity. after aggressive management, she was well for a while. however, she developed to a poor condition consisting of urologic, gastroenterological, hematologic and neurologic problems just in a short time. in the course of hospital she presented one s...

background and aim: carcinoma of the uterine cervix is a significant cause of mortality because of malignancy in women. radiotherapy is a major treatment modality for invasive cervical cancer with good treatment outcome in early-stage patients. however, substantial treatment failures still occur in the advanced-stage patients. in this case report a long term follow up of a 58 years old woman wi...

Since cervical cancer screening with the Papanicolaou smear has become widespread, the incidence of invasive cervical cancer in developed countries has dramatically decreased. At the same time, the detection of cervical dysplasia has dramatically increased. Diagnosis, management, and follow-up of preinvasive cervical lesions are now a major public health challenge. With teens becoming sexually ...

BACKGROUND Cervical cancer is a leading cancer in women worldwide. The Papanicolaou test (Pap test) remains the main screening tool; however, it produces high rates of false-negative and false-positive results. Gastrin-releasing peptide is a growth factor that has been implicated in many cancers, and its main receptor, the gastrin-releasing peptide receptor (GRPR), is nearly always expressed in...

Cervical erosion, a common gynaecological finding,either has inflammatory or neoplastic origin. Colposcopy and guided biopsy help in differentiating inflammatory lesions from neoplastic lesions. The objectives were to study various colposcopic findings in cervical erosions, to co-relate colposcopy findings with histopathology of cervical biopsy and to find out the outcome of different treatment...