OBJECTIVE To describe the natural history of intraocular pressure (IOP) within the first 30 minutes after intravitreal injection of triamcinolone acetonide (TA). DESIGN Prospective, interventional, consecutive case series. PARTICIPANTS Thirty-eight consecutive patients who met inclusion and exclusion criteria and underwent intravitreal injection of 0.1 ml (4 mg) of TA were studied. METHOD...

Diabetic macular edema (DME) resembles a chronic, low-grade inflammatory reaction, and is characterized by blood-retinal barrier (BRB) breakdown and retinal capillary leakage. Corticosteroids are of therapeutic benefit because of their anti-inflammatory, antiangiogenic, and BRB-stabilizing properties. Delivery modes include periocular and intravitreal (via pars plana) injection. To offset the s...

PURPOSE To investigate the changes in plasma concentrations of vascular endothelial growth factor (VEGF), insulin growth factor (IGF-1), erythropoietin, pigment epithelium-derived factor, and IgG1 after bevacizumab intravitreal injection in infants with retinopathy of prematurity. METHODS Eleven eyes from six infants who received intravitreal injection of bevacizumab were enrolled in this stu...

Self-Plugging Microneedles In article number 2102599, Jeong Hun Kim, WonHyoung Ryu, Ali Khademhosseini, and co-workers, develop self-plugging microneedles (SPM) for intravitreal injection. Once injected, the end of SPM is swollen to seal incision due injection rest delivers drugs desired duration. Unlike general injections, doesn't need additional sealing procedures, so this manner lowers possi...

PURPOSE We report a case of infectious endophthalmitis that developed after the third intravitreal injection of bevacizumab. The endophthalmitis was caused by Staphylococcus epidermidis. METHODS Observational case series. RESULTS This was a case of a 77-year-old man who had received three intravitreal injections of bevacizumab and developed infectious endophthalmitis. Polymerase chain react...

purpose: to study the effects of adding intravitreal bevacizumab (avastin) to conventional laser treatment on regression of retinal neovascularization in threshold rop. methods: intravitreal injection of bevacizumab (1.25 mg) in one eye of each of three newborns with threshold rop was performed in addition to laser treatment. the other eye of each patient was treated with laser alone. changes i...

purpose: to report an idiopathic retinal vasculitis, aneurysm, neuroretinitis (irvan) case treated with one session of panretinal photocoagulation (prp) and intravitreal bevacizumab (avastin) case report: a 13-year-old boy was diagnosed as an irvan syndrome. systemic examination, fundus angiography, brain mri were performed to evaluate the patient. treatment with one session of prp, retinopexy ...

purpose: to determine if intravitreal injection of triamcinolone acetonide is safe and effective in the treatment of diabetic macular edema unresponsive to prior laser photocoagulation. methods: fifty-four eyes of 38 patients with clinically significant macular edema which had received at least two sessions of laser photocoagulation according to early treatment diabetic retinopathy study guidel...

PURPOSE To report the presenting features and clinical outcomes of a series of patients with noninfectious inflammation after intravitreal aflibercept injection. DESIGN Noncomparative consecutive case series. METHODS Medical records of patients who presented with noninfectious inflammation after intravitreal aflibercept injection between November 18, 2011 and June 30, 2013 were retrospectiv...

PURPOSE To report two cases of chronic postoperative cystoid macular edema, resistant to topical therapy, treated with consecutive intravitreal injections of ketorolac tromethamine. METHODS Four daily intravitreal injections of 500 μg/0.05 mL of ketorolac were given to each patient. Complete clinical examination and OCT were performed before every injection, 1, 2, 3 weeks, and 1, 3, and 6 mon...