Abstract Vitamin C (L-ascorbic acid) works as a strong reductant, radical scavenger, and protector of cell membranes against primary peroxidative damage in tissues the extracellular fluid. L-ascorbic acid is involved synthesis collagen many other biologically relevant substances, enzyme activity, xenobiotic detoxification, prevention forming carcinogenic nitrosamines. It also plays role immune ...

Vitamin E (alpha-tocopherol) is a potent and natural antioxidant. Vitamin E is concentrated from soybean oil. The Committee on Fetus and Newborn of the Academy of the American of Pediatrics endorsed 1 to 2 mg/dl as the normal range of serum tocopherol level. Human infants are born with low stores of vitamin E, thus they require an adequate intake of vitamin E soon after birth. The optimum intra...

e nuclear accident in Fukushima, Japan, in March 2011 led to drastic mechanistic measures (e.g., evacuation, decontamination showers of clothing, and use of protective clothing by rescue workers) to protect the population against imminent and future radiation exposure. Besides mechanistic measures, no orthomolecular protection measures other than iodine supplementation were taken, although scie...

products of lipid peroxidation (F2-isoprostanes) in smokers. Smoking as a cause of oxidative damage. N Engl J Med 1995; 332: 1198–1203 2. Handelman GJ, Walter MF, Adhikarla R et al. Elevated plasma F2-isoprostanes in patients on long-term hemodialysis. Kidney Int 2001; 59: 1960–1966 3. Patrono C, FitzGerald GA. Isoprostanes: potential markers of oxidant stress in atherothrombotic disease. Arter...

Methods Formation of MP was studied in 8 healthy male subjects exposed to intravenous E. coli endotoxin (LPS; 2 ng/kg body weight) who were re-challenged after 17 ± 11 days. In addition, intravenous vitamin C (25 g) or placebo was administered 3.5 hours after LPS on alternate trial days in random order. Venous blood samples were taken before, 3 h and 6 h after LPS administration. MP were detect...

Vitamin D or vitamin D analogues pulse therapy is seldom effective in patients with at least one parathyroid gland with nodular hyperplasia, and surgical parathyroidectomy or parathyroid intervention is indicated. In parathyroid interventions, especially in selective percutaneous ethanol injection therapy (PEIT), the enlarged parathyroid gland(s) with nodular hyperplasia is selectively destroye...

this investigation determined that vitamin c intake of c.w. was higher than o.p. , s. c. and c. statistically, there was a significant difference between c.w. and c. blood ascorbic acid levels of o.p. and s.c. were lower than c.w. and c. , a significant difference was observed. urinary vitamin c in all groups was lower than controls and this indicates that even though vitamin c intake was high,...

Low-molecular-weight and unfractionated heparins are frequently used to treat venous thromboembolism, but it is not known whether they are equally effective in inhibiting in vivo generation of thrombin. In this multicenter trial, 1048 patients were randomized to intravenous unfractionated heparin (group A), twice daily low-molecular-weight heparin (reviparin) for 1 week (group B), or once daily...