INTRODUCTION Metastatic tumors are the most common intraocular malignancies in adults. Anterior segment metastases account for about 7.2-14.1% of all intraocular metastatic tumors with those to the iris representing 3.6-7.8% of the cases. Breast and lung are the most frequent primary sites of metastasizing cancer. The aim of this study is to present the case of a 43-year-old patient with a rare...

The expression of cyclooxygenase-2 (COX-2) has been reported as an indicator of poor prognosis in a wide variety of human tumors, including colon, breast and uveal melanoma (UM). COX-2 inhibitors have shown promise in controlling the malignancy of several types of tumors. Previous studies have demonstrated the efficacy of a COX-2 inhibitor on the proliferation rates of human UM cells. The goal ...

SEPTEMBER 2009 I RETINA TODAY I 65 M asquerade is most often used in ophthalmology in reference to tumors that mimic intraocular inflammation. In this context, a masquerade is not always the result of a tumor, it can also be due to a degenerative process such as retinitis pigmentosa, siderosis, infection, or drugs. In the current context we will refer to intraocular tumors that are mistaken for...

The interior of the eye, or uvea, is a site of immune privilege where certain immune responses are attenuated or completely excluded to protect non-regenerating tissues essential for vision. One consequence of this immunoregulation is compromised immune mediated elimination of intraocular tumors. For example, certain murine tumor cell lines which are rejected by host immune responses when trans...

Shlomo Dotan, MD Department of Ophthalmology, Hebrew University Hadassah Medical Center, Jerusalem, Israel ABSTRACT Purpose: To demonstrate that slow-growing intracranial suprasellar mass lesions can be associated with optic disc cupping, clinically indistinguishable from glaucomatous optic neuropathy. Cases: At a neuro-ophthalmology tertiary clinic, a retrospective chart review identified four...

Uveal melanoma is the most common primary intraocular malignancy in adults. Localized tumors are often curable by local therapy, but about 50% of patients develop a relapse with metastatic disease, particularly in the liver. Mortality rate after detected liver metastases remains high, while systemic therapies usually provide marginal benefit. Melanomas are hypervascular tumors, and agents with ...

Application of knowledge discovery in databases (data mining) for medical decision support is discussed in this work. The aim of the study was to use decision support algorithm for the differential diagnosis of intraocular tumors using parameters from eye images obtained by the ultrasound examination. Application of predictive modeling algorithm for decision tree formation using See5.0/C5.0 dat...

Bilateral acute depigmentation of the iris (BADI) is a new clinical entity of unknown etiology and is characterized by bilateral, symmetrical, and simultaneous depigmentation of the iris with focal or diffuse stromal atrophy; this condition generally has a good prognosis. We present a case of a 26-year-old woman who noted a spontaneous change in the iris color in both eyes in the last 2 months....

Background: Since the first intraocular biopsy performed in 1868 [1] by Hirshberg and experience published by Jackobiec in 1979, fine-needle aspiration biopsy (FNAB) in the eye has been used for several intraocular tumors [2]. In developed countries there is wide experience regarding intraocular FNAB, in contrast to developing countries where this diagnostic tool has been left aside. Aim/Object...

non-hodgkin lymphoma (nhl) is one of the masquerade syndromes of malignant melanoma that can occur with two main patterns of presentations in the eye: metastatic involvement of uveal tract, and primary involvement of retina. we report ophthalmic, imaging and histopathological findings in the first case diagnosed as primary choroidal nhl without central nervous system or systemic involvement. a ...