Inadequate coronary vasodilator reserve, 1 luminal narrowing of coronary capillaries, and systolic compression of the intramyocardial small arteries are considered to contribute towards myocardial ischaemia in patients with hypertrophic cardiomyopathy (HCM). Previously, abnormal phasic coronary flow velocity pattern in the left anterior descending coronary artery (LAD) in patients with HCM, whi...

OBJECTIVES To determine the safety of intramyocardial injection of autologous bone marrow cells in patients undergoing surgical myocardial revascularization (CABG) for severe coronary artery disease. INTRODUCTION There is little data available regarding the safety profile of autologous bone marrow cells injected during surgical myocardial revascularization. Potential risks include arrythmias,...

We have measured the effects of barium-induced cardiac contraction on the intramyocardial blood volume content of all vessels and have independently measured the blood volume content of vessels with a diameter greater than 100 ,um in rat myocardium. Measurements of total intramyocardial blood volume were made by using [1251]albumin as a plasma marker and technetium-99m as a red blood cell marke...

UNLABELLED There is a need for in vivo monitoring of cell engraftment and survival after cardiac cell transplantation therapy. This study assessed the feasibility and usefulness of combined PET and MRI for monitoring cell engraftment and survival after cell transplantation. METHODS Human endothelial progenitor cells (HEPCs), derived from CD34+ mononuclear cells of umbilical cord blood, were r...

Effective local delivery to the heart remains an obstacle to successful therapeutic application of a number of drugs and biological agents. This study was designed to study and optimize the delivery characteristics of transendocardial intramyocardial (IM) administration, determine myocardial deposition and retention over time, and compare it to transepicardial IM injection. Thirty-nine pigs wer...