1. Cefoperazone is a third generation semi-synthetic cephalosporin with a broad spectrum of activity against the majority of aerobic and anaerobic gram-positive and gram-negative pathogenic bacteria in vitro. Cefoperazone sodium and -dihydrate are used for intramammary treatment of clinical mastitis in lactating cattle. Dose levels used are 250 mg cefoperazone sodium per infected quarter once o...

648 Effect of altering the ratio of dietary n-6 to n-3 fatty acids on lactational performance and acute phase response to an intramammary lipopolysaccharide challenge. L. F. Greco*1, J. T. Neves Neto1, A. Pedrico1, R. Ferrazza1, F. S. Lima1, R. S. Bisinotto1, N. Martinez1, E. S. Ribeiro1, M. Garcia1, G. C. Gomes1, M. A. Ballou2, W. W. Thatcher1, C. R. Staples1, and J. E. P. Santos1, 1University...

This work investigates the pharmacodynamic effectiveness of cefquinome against environmental Escherichia coli mastitis infection, following an intramammary administration. We established the pharmacokinetic and pharmacodynamic (PK/PD) model in lactating mice. The PK/PD parameters were identified to achieve an antibacterial efficacy as indicated by PD activity, cytokine expression and PK/PD simu...

Efficacy of premiliking teat disinfection (predipping) with good udder preparation was compared with good udder preparation alone on four well-managed, commercial dairy farms. Three teat dip formulations containing iodophor were used for predipping. Predipping reduced the rate of intramammary infection with major mastitis pathogens approximately 54%. Infection rate with esculin-positive strepto...

2. Thiamphenicol is used for the treatment and control of respiratory and intestinal infections in cattle and poultry; the routes of administration are oral or intramuscular. However, the substance is also intended for intramammary administration in both lactating and dry cows and for intrauterine administration in cows. Thiamphenicol is used for the treatment of pigs against respiratory and in...

Schwannomas are benign tumors arising from the peripheral nerve sheath, commonly occurring in the head, neck, and extensor surfaces of the extremities. They can be associated with neurofibromatosis type II. Our case describes a 48-year-old woman with a 2-week history of a left-sided palpable breast mass. She was referred to radiology, where additional imaging revealed a 1.1-cm mass. A biopsy wa...

The prevention of bovine mastitis is the most important component of a mastitis control program, and both preand postmilking teat antisepses are the most effective procedures for preventing new intramammary infections (IMI) in dairy cows. These procedures involve dipping teats of dairy cows before and after milking with an appropriate germicidal preparation to reduce teat skin colonization and ...