In our series, Intra‐arterial Chemotherapy (IAC) was carried out in all patients by placing the microcatheter close to the origin of the ophthalmic artery where the predominant flow of chemotherapeutic agent was guided into the ophthalmic artery and controlled by intermittent fluoroscopic screening and manual hand injection. The manual injection was pulsatile with the adequate pressure of injec...

PURPOSE Preclinical studies demonstrate that cardiac glycosides such as ouabain and digoxin have antitumor effects on retinoblastoma cells in vitro and in a xenograft murine model of retinoblastoma. METHODS Based on these findings, we report a case of intra-arterial followed by systemic oral digoxin therapy in a patient with unilateral retinoblastoma that had failed prior intra-arterial chemo...

1 Increases in renal blood flow were produced by intra-arterial injections of dopamine (5-50 mug) in anaesthetized dogs pretreated with alpha- and beta-adrenoceptor antagonists.2 Intra-arterial administration of ergometrine (0.5 mg) or apomorphine (1 mg) produced a depression of the renal dilator responses to dopamine, without affecting renal dilatations in response to intra-arterial acetylchol...

Intra-arterial histamine was found to increase significantly the walking tolerance of a small series of cases of obliterative peripheral arterial disease with intermittent claudication. Physiologic determinations during injection show tachycardia, increased cardiac output, increased stroke volume and increased homolateral femoral arteriovenous oxygen difference. The similarity of these results ...

In the present study, the effects of intra-dorsal hippocampal (intra-CA1) injections of nitric oxide (NO) agents on muscimol state-dependent memory were examined in mice. A single-trial step-down passive avoidance task was used for the assessment of memory retrieval in adult male NMRI mice. Post-training intra-CA1 administration of a GABAA receptor agonist, muscimol (0.05 and 0.1 μg/mouse) dose...

The role of nucleus tractus solitarius (NTS) in cardiovascular system regulation is controversial. On the other hand, the problem of hypertension in diabetic animals is the subject of many research programs. The aim of present study was to determine whether inactivation of NTS could affect blood pressure and heart rate in diabetic rats. To this end, stereptozotocin induced diabetic rats were an...

Vol. 34 No. 5 • May 2009 • P&T® 243 (see the April issue of P&T, page 175). Ms. Levine sued and received a settlement from the clinic where the drug was administered. She also named Wyeth as a defendant, claiming that the drug’s label should have more clearly instructed clinicians against using an IV push injection. The label, which the FDA had approved, warned about inadvertent intra-arterial ...

background: gonadotropin-releasing hormone agonists or antagonists are used in assisted reproductive technique cycles as premature luteinizing hormone secretion inhibition. studies have been reported different and contradictory results on the serum progesterone effect on intra-cytoplasmic sperm injection. objective: the purpose of this study was to evaluate the effect of serum progesterone leve...