In 2013, the Japan Gastroenterological Endoscopy Society introduced Kyoto classification of gastritis, which is useful to predict Helicobacter pylori infection based exclusively on endoscopic findings. Based gastric mucosal atrophy, intestinal metaplasia, hypertrophic folds, nodularity, and diffuse redness may be associated with cancer H. infection, are common findings in Koreans. Atrophy metap...

The clinical pathological characteristics of 3969 adult patients with chronic atrophic gastritis were retrospectively studied. The positivity of intestinal metaplasia and dysplasia in atrophic gastric specimens increased with age; however, H. pylori positivity and inflammatory activity decreased significantly with increased age. H. pylori infection was present in 21.01% of chronic atrophic gast...

Gastric carcinogenesis (GC) is a multistep and multifactorial process the result of interplay between genetic susceptibility environmental factors. GC involves, in most cases, progression from normal mucosa through chronic gastritis, mucosal atrophy intestinal metaplasia to dysplasia neoplasia. The two diagnostic tools Operative Link on Gastritis Assessment (OLGA) Intestinal Metaplasia (OLGIM) ...

NABEYAMA, A. and OGATA, T. Cytological Studies on the Eaterochrounafin Cells in the Intestinal Metaplasia. Tohoku J. exp. Med., 1971, 105 (4),355-363 The enterochromaffin cells (Ec-cells) in the normal and pathological antral mucosa of the human stomach were examined. It was clarified that the Ec-cells are observed only in the mucosa with intestinal metaplasia, and never in the normal mucosa. W...

firmed these findings in a small group of patients. It appears that destruction of the glandular basement membrane and the immediately surrounding sheath of supporting cells prevents orderly regeneration. When applying a strict definition of atrophy, as proposed by Genta (8), it is highly unlikely that cure of H. pylon infection will result in restitutlo ad integrum i.e., glandular parenchyma r...

Occupational exposure to wood dust is a strong risk factor for the development of intestinal-type sinonasal adenocarcinoma (ITAC); however, knowledge on possible precursor lesions or biomarkers is limited. Fifty-one samples of tumor-adjacent mucosa and 19 control samples of mucosa from the unaffected fossa of ITAC patients were evaluated for histological changes and p53 protein expression. Mild...

BACKGROUND AND STUDY AIMS Yearly surveillance endoscopy is carried out for Barrett's esophagus with low-grade dysplasia (LGD) so that progression to high-grade dysplasia and adenocarcinoma can be detected at the earliest stage. The aim of the study was to assess the long-term safety and effectiveness of circumferential ablation followed by focal ablation (HALO system) for eliminating Barrett's ...

Prolonged inflammation or irritation due to renal calculi can induce glandular metaplasia of the urothelium and even malignant neoplasm. Primary adenocarcinoma in pelvicalyceal system is a rare tumor in such patients. Here, a case of carcinoembryonic antigen (CEA) positive primary tubulovillous adenocarcinoma in pelvicalyceal system is reported. A 57-year-old male with right abdominal pain and ...

Barrett's esophagus is a condition in which the normal squamous lining of the esophagus has been replaced by columnar epithelium containing intestinal metaplasia induced by recurrent mucosal injury related to gastroesophageal reflux disease. Barrett's esophagus is a premalignant condition that can progress through a dysplasia-carcinoma sequence to esophageal adenocarcinoma. Multiple endoscopic ...

Accurate diagnosis of gastric intestinal metaplasia is important; however, conventional endoscopy is known to be an unreliable modality for diagnosing gastric intestinal metaplasia (IM). The aims of the study were to evaluate the interobserver variation in diagnosing IM by high-definition (HD) endoscopy and the diagnostic accuracy of this modality for IM among experienced and inexperienced endo...