A one-month-old male terrier dog was referred in shock status with a history of anorexia, tachypnea, abdominal distention and progressive weight loss. Auscultation of right side of the lungs found enhanced respiratory noises. The thorough auscultation of the opposite side of the chest revealed the presence of typical intestinal sounds. Cardiac auscultation revealed muffled heart sounds and a di...

Crohn's disease (CD) is a complex multisystemic inflammatory disorder and part of the bowel diseases (IBDs). About 20% subjects affected by IBDs are paediatric patients 21% them present extraintestinal manifestations. Among manifestations CD, oral rather frequent (20–50% people) can be difficult to identify, being frequently aspecific not pathognomonic. Their early diagnosis dentist extremely i...

Lynch syndrome is an autosomal-dominant disorder caused by defective DNA mismatch repair (MMR) genes and is associated with increased risk of malignancies in multiple organs. Small-intestinal adenocarcinomas are common initial manifestations of Lynch syndrome. To define the incidence and characteristics of Lynch syndrome-related small-intestinal adenocarcinomas, meticulous familial and clinical...

BACKGROUND Mutations in the NOD2 gene are a significant risk factor to acquire intestinal failure requiring home parenteral nutrition. Tuberculous lymphadenitis is the main manifestation of extrapulmonary tuberculosis. Defects in the innate immunity, including NOD2 mutations, may increase the risk for acquiring infections caused by M. tuberculosis. An association of intestinal failure, mutation...

The breakdown of the intestinal barrier is a common manifestation of many diseases. Recent evidence suggests that vitamin D and its receptor VDR may regulate intestinal barrier function. Claudin-2 is a tight junction protein that mediates paracellular water transport in intestinal epithelia, rendering them "leaky". Using whole body VDR(-/-) mice, intestinal epithelial VDR conditional knockout (...

Cutaneous Crohn’s disease (CCD) is a relatively rare disease. Two-thirds of the affected patients are female with a mean age of onset of 35 years. CCD is divided into a genital type and an extra-genital type, each with their own unique different clinical manifestations. The usual presentation of genital Crohn’s disease (CD) is in the form of erythema and edema of the labia and scrotum. Here, we...

Amyloidosis is a heterogeneous group of diseases in which the extracellular deposition abnormal fibrillar proteins disrupts tissue structure and function. Intestinal involvement very rare manifestation amyloidosis compared to most affected organs, heart kidneys. Damage gastrointestinal tract may be only amyloidosis, or - more often component several organs systemic amyloidosis. Any part digesti...

inflammatory myofibroblastic tumor is an uncommon benign neoplasm and its presentation in small bowel is rare. due to clinical manifestation, laboratory data and radiologic results, there is an increased risk of over diagnosis as malignant tumors particularly malignant lymphoma in childhood therefore may be resulting in wrong therapeutic approach. however pathologic findings could be demonstrat...