Urethral stricture after radiation therapy for localized prostate cancer is a delicate problem as the decreased availability of tissue healing and the close relation to the sphincter complicates any surgical approach. We here review the pathophysiology, dosimetry, and the disease specific aspects of urethral strictures after radiotherapy. Moreover we discuss different treatment option such as d...

A semi-automatic procedure to correlate the motion of lung tumor points in 4D-CT images with a respiratory surrogate signal is presented. Data analysis was performed to characterize of the robustness of external/internal correlation properties in the clinical framework of gated radiotherapy treatments. A cross-correlation based algorithm was implemented to perform template matching for tracking...

In this paper, we study a combinatorial problem arising in the development of innovative treatment strategies and equipment using tunable shields in internal radiotherapy. From an algorithmic point of view, this problem is related to circular integer word decomposition into circular binary words under constraints. We consider several variants of the problem, depending on constraints and paramet...

We are interested in fundamental decision and design problems in human-machine collaboration and skill-augmentation, with a focus on healthcare. Inference and optimization in healthcare are often hard multi-stage stochastic models, but we explore efficient reformulations and heuristics with guarantees. Specifically, we have studied algorithmically grounded solutions for integration of autonomy ...

This paper discusses a kernel ridge regression (KRR) model for motion estimation in radiotherapy. Using KRR, dense internal motion fields are estimated from high-dimensional surrogates without the need for prior dimensionality reduction. We compare the proposed model to a related approach with dimensionality reduction in the form of principal component analysis and principle component regressio...

a Department of Gynecology, Martin-Luther-University, Halle/Saale, Germany; b Division of Hematology-Oncology, Department of Internal Medicine, American University of Beirut, Beirut, Lebanon; c Peter MacCallum Cancer Centre, Melbourne, Australia; d Department of Oncology and Radiotherapy, Medical University of Gda ’ nsk; Gdansk, Poland; e Helen Diller Family Comprehensive Cancer Center, Univers...