OBJECTIVE To assess the immunomodulatory activity of methylthioadenosine (MTA) in rodent experimental autoimmune encephalomyelitis (EAE) and in patients with multiple sclerosis. METHODS We studied the effect of intraperitoneal MTA in the acute and chronic EAE model by quantifying clinical and histological scores and by performing immunohistochemistry stains of the brain. We studied the immuno...

introduction: multiple sclerosis is a chronic inflammatory disease of central nervous system. the etiology of ms is slightly known, but genetic and environmental factors are reported. vitamin d regulates gene expression and affects target cell functions. the aim of this study was to investigate the expression variation of il-2 and il-4 genes under vitamin d supplementation in patients with mult...

Tumour necrosis factor alpha gene (TNF-alpha)-376 polymorphism in Hungarian patients with primary progressive multiple sclerosis. APOE epsilon status in Hungarian patients with primary progressive multiple sclerosis. Validation of the Fatigue Impact Scale in Hungarian patients with multiple sclerosis. Qual Life Res. Factors influencing the health-related quality of life in Hungarian multiple sc...

The aim of this study was to identify the potential compounds, core targets and possible mechanism Huanglian Jiedu decoction in treating ulcerative colitis based on network pharmacology molecular docking. At first, compounds were retrieved from traditional Chinese medicine systems pharmacology. And then, related obtained pharmacology, Online Mendelian Inheritance Man, GeneCards DisGeNET. Next, ...

how to cite this article: naser moghaddasi a. neuroplasticity in early onset multiple sclerosis. iran j child neurol. 2014autumn;8(4): 80-81.   letter to editor, has not abstract. references boiko a, vorobeychik g, paty d, devonshire v, sadovnick d; neurologists. early onset multiple sclerosis: a longitudinal study. neurology 2002; 59(7):1006-10. inaloo s, haghbin s. multiple sclerosis in child...

The adult onset Still’s disease is a rare affection characterised by occurrence of fever, arthralgia or arthritis and evanescent cutaneous eruption. Multiple other systemic lesions make the diagnosis more difficult. Several diagnostic criteria were formulated to confirm this disease. The physiopathology of the adult onset Still’s disease is not well elucidated. However, several studies based on...

dear editor multiple sclerosis (ms) is the most common inflammatory demyelinating disease of the central nervous system. ms is characterized by dissemination in time and place. dissemination can be clinically (clinically definite multiple sclerosis) or radiologically by magnetic resonance imaging (mri). correct diagnosis of ms needs dissemination both in time and in place and also exclusion of ...