Interleukin 1β (IL-1β), the first interleukin to be characterized, plays a key role in regulating the immune response. In this study, we determined the cDNA and genomic DNA sequences of the IL-1β gene from the large yellow croaker, Larimichthys crocea. Phylogenetic analysis indicated that the IL-1β (LcIL-1β) gene was most closely related to that of European seabass (Dicentrarchus labrax), shari...

BACKGROUND Intrauterine infection is a primary cause of preterm birth and fetal injury. The pro-inflammatory role of the fetal skin in the setting of intrauterine infection remains poorly characterized. Whether or not inflammation of the fetal skin occurs in primates remains unstudied. Accordingly, we hypothesized that: i) the fetal primate skin would mount a pro-inflammatory response to preter...

This experiment aims to investigate the effects of partial replacement fish meal (FM) by soybean (SBM) and/or fermented (FSBM) on growth, serum biochemistry, digestion, antioxidation, immunity, and mTOR signaling pathway juvenile coho salmon (Oncorhynchus kisutch). Four iso-nitrogen iso-lipid diets were designed fed four groups (152.25 ± 2.96 g) in triplicate for 10 weeks. The G0 diet (control ...

Objective(s): Asiaticoside (AS) displays anti-inflammation, and anti-apoptosis effect, but the role of AS in hyperoxia-induced lung injury (HILI) treatment is undefined. Therefore, the aim of this study was to investigate the effects of AS on HILI on premature rats and alveolar type II (AEC II) cells.Materials and Methods: Sprague-Dawley...

As a chronic disease, osteoarthritis (OA) leads to degradation of both cartilage and subchondral bone, of which the development is related to proinflammatory cytokines like interleukin-1β. In the present study, the anti-inflammatory effect of Specnvezhenide in osteoarthritis and mechanism of it was studied in vitro and in vivo. The results showed that Specnvezhenide decreases interleukin-1β-ind...

Interleukin 1 (IL-1) and interleukin 6 (IL-6) are typical examples of multifunctional pro-inflammatory cytokines involved in the regulation immune response, hematopoiesis, inflammation. Both peripheral intraventricular administration these causes acute phase symptoms, e.g. fever, activation hypothalamic-pituitary-adrenal axis psychological depression. The amygdala belongs to structures limbic s...

The innate immune response is characterized by activation of transcription factors, nuclear factor kappa B and activator protein-1 and their downstream targets, the pro-inflammatory cytokines including interleukin 1β and interleukin 6. Normal development of this response in the intestine is critical to survival of the human neonate and delays can cause the onset of devastating inflammatory dise...

Abstract The proinflammatory cytokine interleukin-1β (IL-1β) is known to be upregulated in patients suffering from metabolic syndrome. IL-1β contributes insulin resistance obesity and type 2 diabetes, yet its influence on the intestinal microbiome incompletely understood. data presented here demonstrate that mice genetically deficient show a specific alteration of colonisation small group bacte...

Periodontal disease is the leading cause of tooth loss, which also a high-risk factor for other diseases including oral cancer and cardiovascular disease. Periodontitis one most common type periodontal diseases. Interleukin-1β (IL-1β) plays key role in pathogenesis periodontitis. However, mechanism how IL-1β produced during periodontitis still unclear. In present study, we found that human β-de...