Insulin resistance is caused by the inability of target tissues to respond to insulin. Bay leaf (Eugenia polyantha Wight) extract has been used for the treatment of insulin-resistant type-2 diabetes mellitus (IRDM), but it has low solubility and bioavailability. To overcome these problems, chloroform extract of bay leaves was formulated into a self-microemulsifying drug delivery system (SMEDDS)...

conclusions metabolic abnormalities in bscl may prove fatal necessitating optimal therapeutic and preventive measures. patients are advised low fat diet with enhanced physical activities. other treatments include metformin, n-3 polyunsaturated fatty acids and leptin replacement for correction of metabolic complications. we report this case of bscl in view of its rarity. case presentation an 18 ...

background: the correlation of metabolic syndrome and migraine headache was evaluated in some previous studies. however there is no study that compared the prevalence of metabolic syndrome in the patients with and without migraine. control of coincidental factors such as metabolic syndrome reduces therapeutic resistance in migrainous patients. the aim of this study was to compare prevalence of ...

background evidence indicates that insulin resistance results in poor sustained viral response (svr) in patients with chronic hepatitis c (chc). metformin is an oral hypoglycemic agent which improves insulin resistance. methods we sought to determine if the addition of metformin to the treatment regimen could improve svr in treatment-naive chc patients in a randomized, double-blind, placebo-con...

The quality and shelf life of foods of containing lipids (fats and oils) significantly reduces due to rancidity.Applications of natural antioxidants are one of the most effective manners to prevent the oxidation of oils and lipids. The antioxidant properties of juice extracted from barberry fruit (Berberris vulgaris.L) using maceration and SWE (10 bars and 120 180°C) methods were investigated a...

introduction: the use of exercise along with herbal supplements is one of the recommended methods for controlling obesity and its complications, but its effects have been controversial due to the diversity of training programs and also herbal supplements. hence, the objective of this study was to investigate the effects of 10 week ginger and progressive resistance training on c-reactive protein...

objective(s) we determined the effect of a high fructose diet either alone or in combination with iranian shallot or garlic extract on cognitive functions, plasma lipid profile, and the intraperitoneal glucose tolerance test (ipgtt). materials and methods following induction of insulin resistance in fructose-fed rats (fru-fed), they were randomly assigned to three subgroups. the first subgroup ...

background: obesity is a very common disorder resulting from an imbalance between food intake and energy expenditure, and it has a substantial impact on the development of chronic diseases.  the aim of this study was to examine the association of insig2 (rs7566605) gene polymorphism with obesity and obesity associated phenotypes in north indian subjects. methods: the variants were investigated ...

Non-insulin dependent diabetes mellitus, also known as Type 2 diabetes is a polygenic disorder leading to abnormalities in the carbohydrate and lipid metabolism. The major contributors in the pathophysiology of type 2 diabetes (T2D) include resistance to insulin action, β cell dysfunction, an abnormality in glucose metabolism and storage, visceral obesity and to some extent inflammation and oxi...