Insulin resistance is a condition in which insulin signaling and action are impaired in insulin sensitive tissues and results in hyperglycemia, hyperlipidemia and type 2 diabetes mellitus. Our previous studies have shown that rosa damascena has antihyperglycemic effects on diabetic and normal rats. Therefore, we conducted a study to evaluate the effect of this medicinal plant on insulin sensiti...

Background: Many patients with type 2 diabetes are uncontrolled on maximum oral treatment. The early introduction of insulin can lower diabetes-related complications. This study aimed to evaluate type 2 diabetes patients’ demographic characteristics, clinical factors, and attitude toward insulin therapy initiation. Methods: In the present cross-sectional study, 457 patients were selected from 1...

Insulin was discovered 100 years ago but, sadly, across the globe there are significant inequities in access to this life‐saving medicine. Here, authors investigate such inequities, challenges of available and affordable insulin, its delivery systems blood glucose monitoring. Challenges not only include costs but also lack expertise managing diabetes care. Now is time for those community come t...

objective: ganoderma lucidum (g. lucidum) has been suggested to increase serum insulin level.this study was undertaken to investigateits direct effect on the islets of langerhans. material and methods: male albino wistar rats were anesthetized and the islets were isolated after digestion of the pancreas with collagenase. the islets were incubated for 60 min in krebs bicarbonate buffer containin...

In July 1921, researchers in Canada isolated the hormone insulin. This discovery profoundly changed lives of people with diabetes. But insulin remains unaffordable and inaccessible many parts world.

objective: metabolic side effects of the second generation (atypical) antipsychotics have been a forefront of attention since their availability. one common   concern   is   the   development   of   hyperglycemia   and   insulin resistance. the aim of this study was to evaluate the effect of early initiation of omega-3 fatty acids supplementation on glucose-insulin homeostasis in a group of psy...

background: pioglitazone from thiazolidinediones generation, represent a new antidiabetic drugs that have been introduced in the world recently. thiazolidinediones can improve insulin resistance by activating the nuclear peroxoxisome proliferator activated receptor-γ (ppar-γ) and increasing insulin sensitivity in their receptors. insulin and its receptors are found in specific areas of cns with...

background: we investigated the effects of withania somnifera root (ws) on insulin resistance, tumor necrosis factor α (tnf-α), and interleukin-6 (il-6) in fructose-fed rats. methods: forty-eight wistar-albino male rats were randomly divided into four groups (n=12); group i as control, group ii as sham-treated with ws by 62.5mg/g per diet, group iii fructose-fed rats received 10%w/v fructose, a...

Objective(s): The mitogenic effect of the analogous insulin glargine is currently under debate since several clinical studies have raised the possibility that insulin glargine treatment has a carcinogenic potential in different tissues. This study aimed to evaluate the Igf-1r, Insr, and Igf-1 gene expression in colon and liver of streptozotocin-induced diabetic rats in response to insulin glarg...

ABSTRACT Physical activity is known to influence and regulate leptin hormone secretion, which assists in the regulation of body weight and energy homeostasis. The purpose of the present study was to investigate the effects of a single session of concurrent exercise on leptin levels and insulin resistance, until 24 h post-exercise. Ten male subjects (22.9±1.7 years) healthy volunteer perf...