ABSTRACT Sterculia gum is a complex polysaccharide of high molecular weight. The rapid swelling of gum particles, their relative insolubility and their unusual resistance to bacterial and enzymatic breakdown make this gum suitable as a bulk laxative. The present work deals with development of granular formulation using Sterculia gum and its evaluation. The evaluation includes size gradation usi...

Amyloidosis is characterized by the deposition of protein fi brils with a β-sheeted structure. This structure is responsible for the insolubility of the protein fi brils, their resistance to proteolysis and binding affi nity of Congo red dye, and the green birefringence observed with polarized light. In systemic amyloidosis, deposition of amyloid fi brils in (vital) organ systems leads to organ...

colloidal carriers composed of lipids attract much attention in the development of safer and more effective therapy of various diseases. the advantages of lipid-based nanoparticles are illustrated on the example of paclitaxel, a challenging chemotherapeutic drug for the development of a novel and more suitable dosage form for cancer treatment. paclitaxel is known for its water insolubility and ...

Polymethylmethacrylate (PMMA) is a material of choice for many biomedical coating applications. However, such applications are limited due to the toxicity traditional solvents used solution processing PMMA coatings and composites. This problem addressed using an isopropanol-water co-solvent, which allows dissolution high molecular mass fabrication by dip-coating method from concentrated solutio...

Caveolae are striking morphological features of the plasma membrane of mammalian cells. Caveolins, the major proteins of caveolae, play a crucial role in the formation of these invaginations of the plasma membrane; however, the precise mechanisms involved are only just starting to be unravelled. Recent studies suggest that caveolae are stable structures first generated in the Golgi complex. The...

Several screening methods for detecting sickling hemoglobins are presently used in the clinical laboratory (1-6). The present procedure depends on the insolubility of reduced hemoglobin S in a 2.24 mol/liter phosphate buffer. The commercially available “Sickledex” (Ortho Diagnostics, Raritan, N.J. 08869) is also thought to be based on this principle (6). Our method was compared with the standar...

The major intracytoplasmic lesion of Alzheimer's disease is the neurofibrillary tangle (NFT), which is primarily composed of paired helical filaments (PHFs). The mechanism responsible for the formation of PHFs, as well as their insolubility and apparent heterogeneity, is unknown. We found that basic fibroblast growth factor (bFGF) binds to heparinase-sensitive sites in NFTs. bFGF binding is due...

I notice also in the same (May) number of the Indian Medical Gazette some editorial remarks alluding to the suggestion of Ross that the cause might be arsenic. Some in this country, where tin is so plentiful, have thought that metal might be the cause. I think that the insolubility of the ore of tin may exclude that idea. With regard to the suggestion of Ross that it might be arsenic, I think t...

For many years the major problem impeding the elucidation of the structure of melanin and the melanosome has been the insolubility of the melanin polymer. To date, alkaline and acid hydrolysis seem to be the only methods available which can completely solubilize the melanosome (1); unfortunately, both methods degrade the constituents of the organelle other than the melanin polymer. The recent e...